A Trial to Assess the Pain-control Efficacy of Intra-articular Toradol Compared to Oral NSAIDs

The University of Texas System (UT)

Status and phase

Withdrawn

Phase 4

Conditions

Arthritic Knee Pain

Treatments

Drug: Toradol

Drug: Oral NSAID

Study type

Interventional

Funder types

Other

Identifiers

NCT02966288

HSC-MS-16-0616

Details and patient eligibility

About

The study objective is to determine whether a single intra-articular dose of an anti-inflammatory (Toradol) will reduce the need for other analgesic medications and, if so, how long the benefits will last.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with radiographic evidence of osteoarthritis (OA) who present to the ED with a chief complaint of knee pain that the treating provider attributes to their arthritis.

Exclusion criteria

Acute knee trauma
Intra-articular steroid injection within 6 months
History of gout or rheumatoid arthritis
X ray evidence of pathologic fracture, malignancy, or other non-OA cause of symptoms
Signs or symptoms or high risk of acute infection: Recent fevers and chills; Erythema, warmth, or pain out of proportion to exam; History of hemodialysis; History of IV drug use
Lidocaine allergy
Any contraindication to NSAID therapy, including: Allergy; Pregnancy; History of renal insufficiency; History of gastritis, GERD or GI bleeding; Primary care physician's restriction of its use
Contraindication to the procedure, including: Hemophilia; History of total knee replacement of the affected joint
An inability to give informed consent; Active psychosis; Diminished capacity requiring another person to provide consent for medical treatment
An inability to be contacted for follow-up