A Video Intervention to Improve Patient Understanding of Tumor Genomic Testing in Patients With Metastatic Cancer

The Ohio State University

Status: Active, not recruiting

Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Metastatic Malignant Solid Neoplasm; Metastatic Breast Carcinoma; Metastatic Lung Carcinoma; Stage IVB Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8

Treatments: Other: Questionnaire Administration; Behavioral: Health Education

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05215769

NCI-2021-13900 (Registry Identifier)

OSU-21313

R21CA259985 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This clinical trial tests whether a video intervention improves patient understanding of tumor genomic testing in patients with cancer that has spread to other parts of the body (metastatic). Measuring how the video intervention affects patient understanding of tumor genomic testing in patients with metastatic cancer may help doctors provide patient-centered care by effectively communicating the importance of tumor genomic testing.

Full description

PRIMARY OBJECTIVE:

I. To assess change in patient knowledge about tumor next generation sequencing (NGS) following exposure to the video.

SECONDARY OBJECTIVES:

I.To assess changes following exposure to the video, including; Ia. Genomic knowledge via the validated 10 true/false question survey (% correct out of 10).

Ib. 11-item Trust in Physician Survey (TPS) as a single TPS score. Ic. Comparison of results in three patient cohorts: 1) Metastatic breast cancer; 2) lung cancer; 3) metastatic cancer of unspecified type.

EXPLORATORY OBJECTIVE:

I. Assess whether therapies prescribed as a result of tumor NGS achieved clinically favorable result through chart review.

OUTLINE:

Patients participate in a video intervention session and complete questionnaires at baseline, after participating in the video intervention, and after receiving NGS results.

Enrollment: 243 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients must have biopsy-confirmed metastatic cancer
• Be >= 18 years of age
• Be undergoing clinical tumor or circulating tumor deoxyribonucleic acid (DNA) NGS

Exclusion criteria

• Exclude patients who are not English- or Spanish-speaking

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

243 participants in 1 patient group

Health services research (video)

Experimental group

Description:

Patients participate in a video intervention session and complete questionnaires at baseline, after participating in the video intervention, and after receiving NGS results.

Treatment:

Behavioral: Health Education

Other: Questionnaire Administration