A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH)

University of California San Diego

Status: Completed

Conditions: Sexually Transmitted Infections; HIV Infections

Treatments: Behavioral: Experimental

Study type: Interventional

Funder types: Other

Identifiers

NCT01198418

CCTG 592

Details and patient eligibility

About

This is a CCTG sponsored trial in collaboration with UCSD-AVRC investigators to get more information about the methods that are used on the internet to provide information on how to reduce the risk of giving or getting infections that are often or usually passed from one person to another during sexual or intimate contact (sexually transmitted infection (STI)). STIs include chlamydia, gonorrhea and syphilis. The purpose of this study is to develop methods that will allow someone who is living with HIV an easy way that they can get information and learn of ways on their own that can decrease their chances of getting sexually transmitted infections and ways that they can reduce the chance that they may transmit HIV to others.

Full description

Design: CCTG 592 is a randomized, controlled study that will compare the efficacy of web-based intervention to reduce high-risk sexual behavior by persons living with HIV AIDS (PLWH).

Duration: 48 weeks

Sample Size: 200 subjects (100 per arm) that will be randomized

Study Population: HIV-1-infected men who have sex with men (MSM) at least 18 years of age who have a recent history of transmission risk behavior.

Stratification: Subjects will be stratified based upon their baseline antiretroviral use, whether they have a home computer and by site.

Enrollment: 181 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HIV-1 infection, as documented by any licensed screening antibody test, such as ELISA, and confirmed by a second antibody test, such as Western blot, or detectable plasma HIV-1 RNA at any time prior to study entry. If an ELISA or Western Blot are not available, HIV infection may be documented by two HIV RNA values > 2000 copies/mL, drawn at least 24 hours apart. The HIV RNA assays should have been run at a CLIA approved laboratory or equivalent.
• 18 years of age or older.
• Male.
• At least one of the following:
• An HIV negative or unknown status sexual partner in the past three months.
• A sexually transmitted disease in the past 1 year (other than HIV).
• More than 2 male partners in past year.
• Unprotected anal sex in past 3 month.
• Capable of signing written informed consent.
• Read and comprehend English
• Adequate computer skills for study.

Exclusion criteria

• Uncontrolled psychiatric condition.
• Drug or alcohol users with use that in the opinion of the investigator, would limit follow-up and adequate consent

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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181 participants in 2 patient groups

Internet-based counseling

Experimental group

Description:

Completes surveys monthly about their sexual and drug use behaviors as well as receives information designed to help reduce the chances of getting an STI.

Treatment:

Behavioral: Experimental

Survey Alone

No Intervention group

Description:

Completes surveys monthly about their sexual and drug use behaviors