A2 to O Lung Transplants

University Health Network, Toronto

Status: Enrolling

Conditions: Lung Transplant; ABO Incompatibility

Treatments: Procedure: Blood group A2 donor to blood group O recipient lung transplant surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT05581745

21-5005

Details and patient eligibility

About

Blood group A2 to blood group O kidney and liver transplants have been shown to be safe and successful, especially in recipients with low pre-operative anti-A antibody titers and with the use of peri-operative antibody-depleting therapies. Since blood group O lung transplant candidates tend to have longer wait times and a higher waitlist mortality compared to other blood groups, we propose to conduct a prospective study of lung transplantation from blood group A2 donors to eligible blood group O recipients in an effort to increase the available donor pool. The aim of this study is to determine both the feasibility and safety of this specific type of ABO-incompatible lung transplant, and the impact of this practice on reducing transplant wait times among blood group O lung transplant candidates. This would represent the first prospective study of ABO-incompatible lung transplants worldwide.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• first lung transplant
• blood group O recipient
• low pre-operative anti-A antibody titers
• consent to study participation

Exclusion criteria

• re-transplant
• multiorgan transplant
• positive virtual crossmatch at time of transplant

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

A2 donor transplant to O recipient

Experimental group

Treatment:

Procedure: Blood group A2 donor to blood group O recipient lung transplant surgery