ABCDEF Bundle to Prevent Delirium for COPD Patients

Istanbul Saglik Bilimleri University

Status: Not yet enrolling

Conditions: Delirium; Copd; Nurse's Role

Treatments: Other: ABCDEF Bundle to Prevent Delirium; Other: Standard Care to Prevent Delirium

Study type: Interventional

Funder types: Other

Identifiers

NCT06974318

IstanbulSBU-HSBE-EEO-01

Details and patient eligibility

About

Abstract Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder characterized by persistent airflow limitation and chronic respiratory symptoms, resulting from abnormalities in the bronchi, bronchioles, and alveoli. Patients with COPD may require admission to intensive care units (ICUs), particularly during acute exacerbations. In this context, both disease management and the prevention of potential complications, such as delirium, are of critical importance. Delirium is a common, preventable, and serious complication in ICUs that prolongs hospital stays, increases healthcare costs, and heightens the risk of infections. Hypoxia-induced cognitive impairment is among the key contributing factors to delirium in patients with COPD.

To improve patient outcomes, the ABCDEF Care Bundle was introduced in 2013 as a structured and evidence-based approach to ICU care. This study aims to evaluate the effectiveness of the ABCDEF Care Bundle in preventing delirium in patients with COPD admitted to the ICU. The research will be conducted as a randomized controlled trial between April and December 2025 in the third-level ICU of Taksim Training and Research Hospital. The study population will consist of COPD patients, with a total sample size of 84 patients (42 in each group), randomly assigned using a computer-assisted simple randomization method. A variety of validated instruments will be used to assess pain, sedation, cognitive status, mobility, and sleep quality.

The findings of this study are expected to contribute to the growing body of evidence supporting structured ICU care and to raise awareness among healthcare professionals regarding the implementation of the ABCDEF Care Bundle.

Keywords:

ABCDEF Care Bundle, Delirium, COPD, Intensive Care, Nursing Care, Randomized Controlled Trial

Enrollment: 84 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients aged 18 and over,
• No cognitive disease such as dementia or Alzheimer's,
• Patients requiring intensive care monitoring for at least 24 hours,
• Non-intubated patients,
• Having a diagnosis of COPD.

Exclusion criteria

• Patients being monitored in intensive care primarily due to central nervous system disease,
• Intubated patients.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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84 participants in 2 patient groups

Control Group

Other group

Description:

This group will have "Standart Nursing Care" to prevent delirium.

Treatment:

Other: Standard Care to Prevent Delirium

Intervention Group

Experimental group

Description:

This group will have "ABCDEF Bundle" to prevent delirium.

Treatment:

Other: ABCDEF Bundle to Prevent Delirium