Ability of Grape Seed Proanthocyanidins to Reduce Postprandial Triglycerides in Humans

Technological Centre of Nutrition and Health, Spain

Status: Completed

Conditions: Cardiovascular Function; Triglyceride Metabolism

Treatments: Other: 2 empty capsules; Dietary Supplement: 35 mg/Kg of grape seed proanthocyanidins extract (2 capsules)

Study type: Interventional

Funder types: Other

Identifiers

NCT01688154

306724

Details and patient eligibility

About

Grape seed proanthocyanidins have been reported to possess a hypotriglyceridemic effect after an acute or chronic consumption in rodents. In this study, we aimed to investigate the effects of an acute consumption of proanthocyanidins before a breakfast meal in humans. Moreover, the mechanisms implicated in the reduction of plasma triglycerides levels by grape seed proanthocyanidins in humans should be elucidated as well as its activity on vascular function.

Full description

The intervention will consist in the administration of 2 capsules containing the grape seed proanthocyanidins extract or 2 empty capsules (placebo) just before breakfast, which will consist of 100g of white bread, 75g of salami, 50g of fatty cheese, 125g of yogurt (10% fat), 25ml of olive oil and water ad libitum. The nutritional composition of this meal is as follows: 1.200 Kcal of energy content, 15% of energy from proteins, 22% from carbohydrates and 63% from fat (35% saturated fat), and 120mg of cholesterol. Blood samples will be taken at point 0.5,1,2,3 and 6 hours after breakfast. Moreover, urine samples will be collected at time 0 and 6 hours.

Enrollment: 16 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults between the ages of 20 and 40
• Signing the informed consent

Exclusion criteria

• Body mass index (BMI) lower than 18.5 or greater than 27 Kg/m2
• Smokers
• Regular medication
• Consumption of medication during the last week
• Following a weight-loss diet
• Vegetarians
• Abnormal glucose levels
• Diabetes
• Cardiovascular disease
• Gastrointestinal disease
• Anemia
• Nuts allergy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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16 participants in 2 patient groups, including a placebo group

Product 1

Active Comparator group

Description:

35 mg/Kg of grape seed proanthocyanidins extract (2 capsules)

Treatment:

Dietary Supplement: 35 mg/Kg of grape seed proanthocyanidins extract (2 capsules)

Control product

Placebo Comparator group

Description:

2 empty capsules

Treatment:

Other: 2 empty capsules