Abiraterone Acetate in Combination With Docetaxel After Disease Progression to Abiraterone Acetate in Metastatic Castration Resistant Prostate Cancer. (ABIDO)

Spanish Oncology Genito-Urinary Group

Status and phase

Completed

Phase 2

Conditions

Metastatic Prostate Cancer

Treatments

Drug: docetaxel 75 mg/m2 + prednisone 10 mg/d

Drug: docetaxel 75 mg/m2 + prednisone 10 mg/d + abiraterone 1000 mg/d

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02036060

2013-003811-23 (EudraCT Number)

ABIDO-SOGUG

Details and patient eligibility

About

Prostate cancer is the most frequently diagnosed non-skin cancer, and the second leading cause of men cancer death in the United States. Hormonal therapy remains a first-line treatment for metastatic prostate cancer. Initial responses to hormonal therapy with chemical or surgical castration are quite favorable, however, most patients will progress to a castration-resistant phase of the disease. Docetaxel is the primary chemotherapeutic option for patients with mCRPC.

Abiraterone is a novel, selective, irreversible, and potent inhibitor of 17-[alpha]-hydroxylase/17,20-lyase (CYP17) enzymatic activity that has recently been demonstrated to further reduce testosterone levels in the blood to undetectable range (< 1 ng/dL) and is suggested to reduce de novo intratumor androgen synthesis. Abiraterone demonstrated activity in castration resistant prostate cancer patients previously treated with docetaxel chemotherapy. Recently, results of a phase III trial comparing abiraterone plus prednisone vs placebo plus prednisone in asymptomatic and without visceral metastasis, castration-resistant metastatic prostate cancer patients, demonstrated a better radiological progression free survival for abiraterone treated patients and a trend towards a better survival was clear for abiraterone treated patients.

No clinical evidence exists about efficacy of chemotherapy and antiandrogen therapy combination. All trials have been performed in patients in which LHRH agonist treatment was continued although there is not clear evidence about efficacy of hormonal treatment. Some retrospective studies suggest that androgen deprivation treatment should be maintained in chemotherapy treated patients. Abiraterone has been proved to suppress androgen levels to negative values, and to add efficacy to castration hormonal therapy. Combination of abiraterone with docetaxel chemotherapy seems promising adding efficacy to only docetaxel chemotherapy. A randomized phase II study comparing docetaxel + prednisone + abiraterone to docetaxel + prednisone in mCRPC in patients treated previously with abiraterone, seems promising to explore addition of efficacy to taxotere after abiraterone hormonal treatment.

Enrollment

119 patients

Sex

Male

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Willing and able to provide written informed consent
Male aged 18 years and above
Histologically or cytologically confirmed adenocarcinoma of the prostate.
Metastatic disease documented by positive bone scan or metastatic lesions other than liver or visceral metastasis on CT, MRI.
Prostate cancer progression to previous castration treatment documented by PSA according to PCWG2 or radiographic progression according to modified RECIST criteria or bone scan progression
Asymptomatic or mildly symptomatic from prostate cancer
Surgically or medically castrated, with testosterone levels of < 50 ng/dL (< 2.0 nM).
Previous anti-androgen therapy and progression after withdrawal.
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
Hemoglobin >= 10.0 g/dL independent of transfusion
Platelet count >= 100,000/µL
Serum albumin >= 3.5 g/dL
Serum creatinine < 1.5 x ULN or a calculated creatinine clearance >= 60 mL/min
Serum potassium >= 3.5 mmol/L
Liver function: a. Serum bilirubin < 1.5 x ULN (except for patients with documented Gilbert's disease) b. AST or ALT < 2.5 x ULN
Life expectancy of at least 6 months
Patients who have partners of childbearing potential must be willing to use a method of birth control

Exclusion criteria

Active infection or other medical condition that would make prednisone/prednisolone (corticosteroid) use contraindicated
Any chronic medical condition requiring a higher dose of corticosteroid than 10mg prednisone/prednisolone daily.
Pathological finding consistent with small cell carcinoma of the prostate
Liver or visceral organ metastasis
Known brain metastasis
Use of opiate analgesics for cancer-related pain, including codeine and dextropropoxyphene, currently or anytime within 4 weeks of Cycle 1 Day 1
Prior cytotoxic chemotherapy or biologic therapy for the treatment of CRPC
Radiation therapy for treatment of the primary tumor within 6 weeks of Cycle 1, Day
Radiation or radionuclide therapy for treatment of metastatic CRPC
Previously treated with ketoconazole for prostate cancer for greater than 7 days
Prior systemic treatment with an azole drug (e.g. fluconazole, itraconazole) within 4 weeks of Cycle 1, Day 1
Prior flutamide (Eulexin) treatment within 4 weeks of Cycle 1, Day 1
Bicalutamide (Casodex), nilutamide (Nilandron) within 6 weeks of Cycle 1 Day 1
Uncontrolled hypertension (systolic BP >= 160 mmHg or diastolic BP >= 95 mmHg).
Active or symptomatic viral hepatitis or chronic liver disease
History of pituitary or adrenal dysfunction
Clinically significant heart disease
Atrial Fibrillation, or other cardiac arrhythmia requiring therapy
Other malignancy, except non-melanoma skin cancer, with a >= 30% probability of recurrence within 24 months
Administration of an investigational therapeutic within 30 days of Cycle 1, Day 1
Any condition which, in the opinion of the investigator, would preclude participation in this trial.