Ablation of Complex Fractionated Electrograms With or Without Additional Linear Lesions for Persistent Atrial Fibrillation (ADLINE)

German Heart Center Munich

Status: Completed

Conditions: Atrial Fibrillation; Recurrence

Treatments: Procedure: PVI+CFAE+DCC; Procedure: PVI, CFAE, anterior and roof line, DCC

Study type: Interventional

Funder types: Other

Identifiers

NCT02059369

GER-EP-013

Details and patient eligibility

About

While there is a consensus to perform pulmonary vein isolation (PVI) as a cornerstone for paroxysmal and persistent atrial fibrillation (AF), different additional ablation approaches are used for substrate modification: linear lesions, ablation of complex fractionated atrial electrograms (CFAE) or a combination of both. The aim of this study is to determine whether there is a difference in terms of freedom from arrhythmia recurrence between PVI with CFAE ablation in combination or not with linear lesions in patients with persistent AF.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with symptomatic persistent AF
• After PVI +CFAE ablation, no termination into sinusrhythm or atrial tachycardia

Exclusion criteria

• Left atrial thrombus

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 2 patient groups

CFAE ablation

Active Comparator group

Description:

Intervention: Complex fractionated atrial electrograms (CFAE) Ablation

Treatment:

Procedure: PVI+CFAE+DCC

CFAE + Lines

Active Comparator group

Description:

CFAE Ablation followed by linear lesions (anterior and Roof line)

Treatment:

Procedure: PVI, CFAE, anterior and roof line, DCC