Abnormalities of Preoperative Ascending Urethrocystography and Outcomes of Living Donor Kidney Transplantation

Assiut University

Status: Not yet enrolling

Conditions: Kidney Transplantation

Treatments: Procedure: Ascending urethrocystography

Study type: Observational

Funder types: Other

Identifiers

NCT06735066

Kidney transplantation 2024

Details and patient eligibility

About

To evaluate effects of abnormalities in preoperative ascending urethrocystography on the short-term outcomes of LDKT

Full description

The incidence of surgical complications after kidney transplantation (KT) has decreased in recent decades due to improvements in surgical techniques and immunosuppression protocols. However, the preoperative abnormalities of the urinary tract may influence the outcomes of KT. Hence, the preoperative evaluation of the urinary tract is a critical step in the KT process to identify the potential risk factors for poor outcomes .

Ascending urethrocystography (AUC) is a key diagnostic tool to assess the integrity and functionality of the lower urinary tract . It provides detailed insights into the bladder, urethra, vesicoureteral valves, and surrounding structures, identifying any abnormalities that could pose risks during or after KT . Understanding this issue is crucial, as certain urological anomalies may predispose patients to complications such as urinary leaks, infections, or delayed graft function, potentially leading to poorer short-term outcomes .

Although AUC is used indiscriminately as a screening test for urological abnormalities, only 6% of all KT recipients may have abnormal lower urinary tract . Few studies have looked at the yield from AUC and attempted to assess objectively whether certain patients could be selected for KT based on a positive result in AUC . Accordingly, the impact of abnormalities detected in AUC on the short-term outcomes of living donor KT (LDKT) remains inefficiently studied .

This is the rationale to conduct this cohort study on patients undergoing LDKT. We hypothesize that the presence of abnormalities in AUC will influence the surgical outcomes and short-term survival rates after LDKT

Enrollment: 80 estimated patients

Sex: All

Ages: 5 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pediatric and adult patients undergoing LDKT in Assiut Kidney Transplantation Unit.
• Patients with preoperative evaluation by AUC.

Exclusion criteria

• Patients with a primary non-functioning graft after LDKT.
• Patients with missing relevant preoperative or postoperative data.
• Patients refusal to participate in the study.

Trial design

80 participants in 1 patient group

Transplantation group

Description:

adult patients who underwent kidney transplantation

Treatment:

Procedure: Ascending urethrocystography