ABO-Incompatible Kidney Transplants Between Robot-Assisted vs. Open Surgery

Asan Medical Center

Status

Completed

Conditions

Kidney Transplantation

Treatments

Procedure: robot-assisted kidney transplantation

Study type

Observational

Funder types

Other

Identifiers

NCT06287008

2023-0085

Details and patient eligibility

About

While robot-assisted kidney transplantation (RAKT) offers potential benefits such as minimal postoperative pain, better cosmesis, fewer wound infections, and shorter hospital stay, its efficacy in ABO-incompatible (ABO-i) KT compared to open KT (OKT) remains understudied. This study aims to compare ABO-i KT outcomes between RAKT and OKT.

The study utilized data from 29 ABO-i RAKT and 210 ABO-i OKT cases performed at Asan Medical Center from October 2020 to February 2023. Univariate and multivariate analyses were performed to evaluate factors associated with a composite of biopsy-proven acute rejection (BPAR), de novo donor-specific antibodies (DSA), and overall graft failure.

Enrollment

239 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient eligible for living donor ABO incompatible kidney transplantation
Presenting an IsoAgglutinin immunoglobulin G titer (anti-A-B) between 1/8 and 1/128 before operation
Patient older than 18 years and young than 80 years
Patient able to sign an informed consent form

Exclusion criteria

Patient with comorbidities or hypersensitivity that prevent desensitization protocols
Women who are pregnant, or who may become pregnant or breastfeeding women
Subjects under legal protection
Subjects participating in another interventional research protocol or in an exclusion period from another interventional research protocolPatient affiliated with a social security scheme