Absorption Kinetics of Polyphenols in Angel's Plant (Angelica Keiskei)

Tufts University

Status and phase: Completed; Early Phase 1

Conditions: Oxidative Stress

Treatments: Dietary Supplement: Angel's plant (Angelica keiskei); Dietary Supplement: angel's plant (Angelica keiskei)

Study type: Interventional

Funder types: Other

Identifiers

NCT00721643

HNRCA2580

BioGreen 20070301034009

Details and patient eligibility

About

The absorption kinetics of polyphenols in angel's plant (Angelica keiskei), which is a dark green leafy vegetable rich in antioxidant nutrients, will be determined in older adults in this pilot study.

Enrollment: 10 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects (>60 yr, n=5)

• subjects with metabolic syndrome (>60 yr, n=5)

• Subjects who has

  • high fasting plasma glucose (>5.6 mmol/L),
  • central obesity (waist-hip ratio, >0.9 for men, >0.85 for women)
  • either high blood pressure (>130/85 mmHg) or high triacylglycerol (>1.7 mmol/L) will be selected to have metabolic syndrome.

• normal hematological parameters, normal serum albumin, normal liver function, and normal kidney function

• no history of smoking or alcoholism.

Exclusion criteria

• consume >7 alcoholic drinks/wk
• taking cholesterol medication or hormone replacement

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

10 participants in 2 patient groups

1

Experimental group

Description:

Healthy control, 5g dry power of angel's plant (Angelica keiskei)

Treatment:

Dietary Supplement: angel's plant (Angelica keiskei)

2

Experimental group

Description:

Metabolic syndrome, 5g dry powder of angel's plant (Angelica keiskei)

Treatment:

Dietary Supplement: Angel's plant (Angelica keiskei)