Abundance and Distribution of Lipids and Proteins in Nonalcoholic Fatty Liver Disease (NAFLD)

Vanderbilt University

Status: Invitation-only

Conditions: Nonalcoholic Fatty Liver Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00983463

IRB #090657

Details and patient eligibility

About

Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in the United States. The incidence of NAFLD is very similar to that of obesity, type 2 diabetes, and the metabolic syndrome. The investigators hypothesize that there may be a relationship between over-nutrition, decreased physical activity and the development of fatty liver. The purpose of this study is to identify the types of fats and proteins, and the quantity of each, that are associated with increased severity of NAFLD.

Enrollment: 45 estimated patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-65 year of age
• Undergoing elective abdominal or bariatric surgery
• May have normal or elevated ALT/AST levels

Exclusion criteria

• Presence of viral hepatitis
• Significant alcohol use
• Intercurrent infections
• Use of any thiazolidinediones

Trial design

45 participants in 3 patient groups

Obese, bariatric surgery, liver biopsy

Description:

Obese subjects approved and scheduled for bariatric surgery at Vanderbilt University Medical Center

Normal BMI, abdominal surgery, liver biopsy

Description:

Normal weight subjects having elective abdominal surgery at Vanderbilt University Medical Center.

Liver transplantation donors and recipients

Description:

All livers made available for implantation or explantation will be eligible.