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Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing. (SAOS)

A

Assistance Publique - Hôpitaux de Paris

Status

Completed

Conditions

Obstructive Sleep Apnea

Treatments

Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Study type

Interventional

Funder types

Other

Identifiers

NCT02876653
P091110

Details and patient eligibility

About

Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)

Enrollment

53 patients

Sex

Male

Ages

20 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Patient:

  • Men aged 20 to 65 years
  • Having polysomnography in the Functional Explorations department, Sleep Laboratory, Hospital Henri Mondor, Creteil
  • With an AHI > 5 / h

Healthy volunteers:

  • Men aged 20 to 65 years
  • With an AHI ≤ 5 / h

Exclusion Criteria

All subjects:

  • Known cardiovascular risk: hypertension treated, diabetes treated, dyslipidemia treated,
  • Known cardiovascular disease associated (heart failure, rhythm disorder ...)
  • Known respiratory diseases
  • Known neoplastic pathology, known chronic inflammatory disease
  • Psychiatric pathology treated
  • Medication
  • Not affiliated to the French social health care system
  • Major protected person
  • Private person of liberty
  • People in emergency situation
  • Patient refusing to participate in the study

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

53 participants in 3 patient groups

Severe OSA
Other group
Description:
Patients with severe OSA (AHI \> 30)
Treatment:
Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations
Moderate OSA
Other group
Description:
Patients with moderate OSA (5 \< AHI ≤ 30)
Treatment:
Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations
Healthy volunteers
Other group
Description:
Healthy volunteers (AHI ≤ 5)
Treatment:
Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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