Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing. (SAOS)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Obstructive Sleep Apnea

Treatments: Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Study type: Interventional

Funder types: Other

Identifiers

NCT02876653

P091110

Details and patient eligibility

About

Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)

Enrollment: 53 patients

Sex: Male

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Patient:

• Men aged 20 to 65 years
• Having polysomnography in the Functional Explorations department, Sleep Laboratory, Hospital Henri Mondor, Creteil
• With an AHI > 5 / h

Healthy volunteers:

• Men aged 20 to 65 years
• With an AHI ≤ 5 / h

Exclusion Criteria

All subjects:

• Known cardiovascular risk: hypertension treated, diabetes treated, dyslipidemia treated,
• Known cardiovascular disease associated (heart failure, rhythm disorder ...)
• Known respiratory diseases
• Known neoplastic pathology, known chronic inflammatory disease
• Psychiatric pathology treated
• Medication
• Not affiliated to the French social health care system
• Major protected person
• Private person of liberty
• People in emergency situation
• Patient refusing to participate in the study

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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53 participants in 3 patient groups

Severe OSA

Other group

Description:

Patients with severe OSA (AHI \> 30)

Treatment:

Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Moderate OSA

Other group

Description:

Patients with moderate OSA (5 \< AHI ≤ 30)

Treatment:

Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Healthy volunteers

Other group

Description:

Healthy volunteers (AHI ≤ 5)

Treatment:

Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations