Accelerated Intermittent Theta Burst Stimulation in Unipolar Versus Bipolar Depression

Mansoura University

Status: Not yet enrolling

Conditions: Depressive Disorder

Treatments: Device: TMS; Device: Transmagnetic stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT06422559

MD.22.12.731

Details and patient eligibility

About

The goal of this interventional study is to learn if accelerated Intermittent Theta Burst Stimulation can improve symptoms of 30 participants with Unipolar depression in higher manner than symptoms of 30 participants with bipolar depression

Full description

We will apply stimulatory TMS protocol for participants with Unipolar depression and participants with bipolar depression using MagVenture MagPro R30 stimulator with the Cool-B65 coil

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age:18_65 years
• Sex:male and female
• Patients with Unipolar depression and bipolar depression diagnosis confirmed by SCID according to DSM5
• No pharmacological change in the last 4 weeks before the beginning of the stimulantion cycle
• Pharmacological resistance

Exclusion criteria

• Patients complaining of psychosis.Substance Use Disorder.current suicidal ideation.major medical and neurological disorder
• Patients complaining of epilepsy
• pregnancy and breastfeeding
• peacemaker spinal or bladder stimulator
• History of skull surgery and trauma
• presence of metallic foreign body

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Participants with unipolar depression

Experimental group

Description:

Participants with Unipolar depression will receive 30 sessions of TMS.10 sessions a week for 3 weeks

Treatment:

Device: TMS

Device: Transmagnetic stimulation

Participants with bipolar depression

Experimental group

Description:

Participants with bipolar depression will receive 30 sessions of TMS.10 sessions a week for 3 weeks

Treatment:

Device: TMS

Device: Transmagnetic stimulation