Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda (ADUNU)

Cincinnati Children's Hospital Medical Center

Status: Enrolling

Conditions: Rheumatic Heart Disease

Treatments: Other: ADUNU program for delivery of RHD care services

Study type: Interventional

Funder types: Other

Identifiers

NCT05783375

2022-0714

Details and patient eligibility

About

The goal of this prospective study is to evaluate the feasibility, sustainability, and public health impact of a district-based program for secondary prevention of Rheumatic Heart Disease (RHD) in Uganda.

Full description

ADUNU is a non-randomized experiment, testing a strategy for implementing an evidence-based practice, decentralized RHD preventive services.

The objectives of the study are to:

Objective 1: Demonstrate the impact of ADUNU, using the RE-AIM framework to assess program Reach, Effectiveness, Adoption, Implementation and Maintenance.

Objective 2: Estimate the cost-effectiveness and budget impact of ADUNU.

ADUNU is a public health initiative that will be deployed the Uganda ministry of health in partnership with the District Health Offices (DHO) in two districts. The program will be overseen by the Technical and Quality Assurance (TAQA). ADUNU's main components will include a RHD testing program which consists of community and facility based echocardiographic screening of children and young adults and a registry based secondary prophylaxis injections of Benzathine penicillin G (BPG) at local health centers III and IVs in both districts.

Enrollment: 221 estimated patients

Sex: All

Ages: 5+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• residing in one of two involved districts in Uganda
• providers at HCIIIs and HCIVs located in one of two involved Ugandan districts

Exclusion criteria

• None

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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221 participants in 1 patient group

ADUNU Participants

Other group

Description:

Individuals and healthcare providers residing and working in the involved Ugandan Districts.

Treatment:

Other: ADUNU program for delivery of RHD care services