Accelerating Post-exercise Muscle Glycogen Resynthesis in Humans: Impact of Combined Nutrient Intake and Intermittent Pneumatic Compression or Heat Therapy

PepsiCo

Status: Completed

Conditions: Glycogen Depletion; Muscle Soreness; Muscle Recovery

Treatments: Other: Nutrient Intake (beverage); Device: Heat therapy; Procedure: Skeletal muscle biopsy; Device: Compression sleeve; Other: Glycogen-depleting exercise session

Study type: Interventional

Funder types: Industry

Identifiers

NCT04371237

PEP-1723

Details and patient eligibility

About

To determine if modalities designed to improve blood flow combined with post-exercise nutrient intake will improve replenishment of muscle glycogen better than nutrient intake alone. A secondary objective is to compare the effectiveness of heat therapy and intermittent pneumatic compression on glycogen replenishment.

Enrollment: 26 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Subjects will be male and female participants in good health
2. 18-35 years of age
3. Currently performing cardiovascular or intermittent exercise at a moderate to high intensity at least 5 days per week for 60 minutes or longer per day.
4. Understanding of the procedures to be undertaken as part of the study
5. Willingness to participate in exercise testing and follow instructions provided by the experimenter
6. Informed, voluntary, written consent to participate in the study

Exclusion criteria

1. History of deep vein thrombosis
2. Obesity (BMI > 30 kg/m2)
3. Hypertension (resting SBP > 140/90 mmHg)
4. Smoking
5. Pregnant, planning to become pregnant, or lactating
6. Supplements containing antioxidants including vitamin C and E and N-acetyl cysteine
7. Any medication
8. Lactose intolerance
9. Participation in another study within the previous 30 days or in a PepsiCo funded study within the past 6 months.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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26 participants in 2 patient groups

Intermittent pneumatic compression

Experimental group

Description:

IPC sleeve device on leg

Treatment:

Other: Glycogen-depleting exercise session

Device: Compression sleeve

Procedure: Skeletal muscle biopsy

Other: Nutrient Intake (beverage)

Heat therapy

Experimental group

Description:

Custom water-circulating garment on leg

Treatment:

Other: Glycogen-depleting exercise session

Procedure: Skeletal muscle biopsy

Device: Heat therapy

Other: Nutrient Intake (beverage)