Acceleration of Orthodontic Tooth Movement

Tishreen University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Mild to Moderate Anterior Mandibular Segment Crowdind

Treatments: Other: serum; Drug: Dihydroxycholecalciferols; Other: dimethyl sulfoxide

Study type: Interventional

Funder types: Other

Identifiers

NCT05560919

Tishreen U _Orthodontics

Details and patient eligibility

About

EVALUATION OF EFFICACY OF LOCALLY INJECTED Vitamin D3 (calcitriol or 1.25 dihidroxicolecalciferol) IN ACCELERATING ORTHODONTIC MOVEMENT Design: A randomized, controlled, crossover, double-blind clinical study including Eighteen adult , aged 15-25 years old.

Full description

The rate of orthodontic tooth movement depends on two general factors: the forces used in order to cause orthodontic tooth movement and respectively the individual (biological) response of the body to these forces.

There are many methods for accelerating orthodontic tooth movement. but, every method has its disadvantages, such as pain and root absorption. Locally injected of vitamin d3 was proposed to accelerates tooth movement with minimal disadvantages, but there aren't enough clinical studies to prove this claim.

Enrollment: 18 patients

Sex: All

Ages: 15 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mild to moderate crowding of mandible teeth. In accordance with LITTLE'S IRREGULARITY INDEX
• Healthy patient
• No previous orthodontic treatment
• Vital teeth with periodental tissue without root absorption,

Exclusion criteria

• Previous history of orthodontic or orthopedic treatment.
• Presence of craniofacial anomalies.
• Presence of any signs and symptoms of gingival and periodontal diseases.
• Presence of significant medical history (including drug allergy).
• Pregnant and lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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18 participants in 3 patient groups

Group 1

Experimental group

Description:

Six participants were bonded with 0.022 × 0.028 inch slot brackets (Ortho Smile) using pre-adjusted edgewise appliance with 0.022 MBT prescriptions. Local periodontal injection of 1,25 DHC at weekly interval (3 times). The gingival fluid volume will measured befor and after 1-1.5 hours after first injection. the same is done visit at the second and third visits. Pain during injection and treatment will be assessed using the FLACC scale and face scale

Treatment:

Drug: Dihydroxycholecalciferols

Group 2

Experimental group

Description:

Six participants were bonded with 0.022 × 0.028 inch slot brackets (Ortho Smile) using pre-adjusted edgewise appliance with 0.022 MBT prescriptions. Local periodontal injection of dimethylsulfoxide at weekly interval (3 times). The gingival fluid volume will measured befor and after 1-1.5 hours after first injection. the same is done visit at the second and third visits. Pain during injection and treatment will be assessed using the FLACC scale and face scale.

Treatment:

Other: dimethyl sulfoxide

Group 3

Experimental group

Description:

Six participants were bonded with 0.022 × 0.028 inch slot brackets (Ortho Smile) using pre-adjusted edgewise appliance with 0.022 MBT prescriptions. ocal periodontal injection of serum at weekly interval (3 times). The gingival fluid volume will measured once. Pain during treatment will be assessed using the FLACC scale and face scale.

Treatment:

Other: serum