Accumbofrontal Tract Study in 2 Populations of Patients With Anorexia Nervosa and Obsessional Compulsive Disorder and Healthy Volunteer (ACCUMBENS)

Poitiers University Hospital

Status

Completed

Conditions

Accumbo Frontal Tract

Treatments

Radiation: Multimodal MRI with diffusion sequence for anorexia nervosa patient

Radiation: Multimodal MRI with diffusion sequence for healthy volunteer

Radiation: Multimodal MRI with diffusion sequence for obsessional compulsive disorder patient

Study type

Interventional

Funder types

Other

Identifiers

NCT03496285

ACCUMBENS

Details and patient eligibility

About

Restrictive anorexia nervosa and TOCs are psychiatric diseases which shares a common pathophysiological substrate We hypothesize that anorexia patients and patients with OCD have structural and functional changes in the accumbofrontal tract. The main objective of this study will be to compare the structure and the connectivity of this tract in MRI with diffusion sequences (DTI tractography) and resting-state, in 3 distinct populations of anorexic patients, patients with OCD and healthy patients. The role of the accumbo-frontal tract in the cortico-striato-hypothalamo-cortical circuit seems to be established. DTI tractography will allow the measurement of functional anisotropy (FA), a parameter that evaluates the diffusion of water molecules along the white matter fibers, and therefore the potential alteration of the studied tract. Resting state sequences will allow to estimate the BOLD signal and the functionality of the tract.

Enrollment

30 patients

Sex

Female

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Female patients
Age between 18 and 65 years
Subjects free to give their written consent

For anorexia nervosa :

Patients meeting the diagnostic criteria for anorexia nervosa according to DSM5 (American Psychiatric Association): low weight (<85% of expected weight for age and height), fear of gaining weight or becoming fat, distortion of body image, and amenorrhea for more than 3 months
Treatment with at least one antidepressant and one anxiolytic

For OCD :

Patients meeting the diagnostic criteria of OCDs according to DSM5 (American Psychiatric Association) : presence of obsessions and / or compulsions, resulting in clinically significant suffering (loss of at least one hour per day) or impairment at the social, occupational level or in another important area of life. These symptoms are not due to the physiological effects of a substance or a general medical condition and cannot be better explained by the symptoms of another psychiatric disorder.
Patients with homogeneous OCD in obsession and compulsion.
Normal weight compared to expected weight for age and height
Treatment with at least one antidepressant and one anxiolytic

ForHealthy volunteer

•Normal weight compared to expected weight for age and height

Exclusion criteria

Male
Age <18 years or> 65 years
Pregnancy
Absence of free and informed consent signature
Current processing by rTMS
Somatic intercurrent pathologies: neurological, cardiological, pneumological, renal, hepatic, endocrine, metabolic disorders ...
Mental retardation (WAIS-IV QI <70)
Primary Amenorrhea
Absolute contraindication or relative to the realization of a magnetic resonance imaging without injection of contrast medium
Old or intercurrent psychotic pathology