Accuracy of FNAC in Thyroid Nodules Compared to to Surgical Specimen : QOC Experience (Thyroid FNAC)

Qena Oncology Center

Status: Completed

Conditions: Thyroid Diseases; Fine Needle Aspiration Cytology

Treatments: Procedure: Fine Needle Aspiration Cytology

Study type: Interventional

Funder types: Other

Identifiers

NCT05521594

Qena Oncology Center 2

Details and patient eligibility

About

Thyroid gland diseases are the second most common endocrine disease following diabetes mellitus(1). Thyroid nodules are common disorders with a prevalence ranged from 4 to 7% in adult population, 5%-30% are malignant [1].Fine-needle aspiration cytology (FNAC) is an easy, cost-effective test for cancer diagnosis, and its use has markedly decreased the number of unnecessary thyroid surgeries(2).

Full description

it should be noted that FNAC cannot differentiate between benign and malignant follicular neoplasms.differentiation between follicular adenoma and follicular carcinoma is only possible after thyroid lobectomy.[2,3] In addition, a study of FNAC showed that 68% of the cases diagnosed by FNAC as follicular neoplasm turned out to be the follicular type of papillary carcinoma, indicting a considerable overlap between benign and malignant neoplasms.[4] Incidental findings of thyroid nodules have increased exponen¬tially in recent years, mostly due to the widespread application of high-resolution ultrasound (US) to the thyroid [5].Several in¬ternational scientific societies have established clinic-radiolog¬ical guidelines for the diagnosis and the management of thy¬roid nodules [2,3]. The American College of Radiology identifies 5 radiological risk levels and recommends US-guided fine-nee¬dle aspiration cytology (US-FNAC) of high-suspicion nodules if 10 mm or larger, and of nodules with a low risk for malignan¬cy only if larger than 25 mm [2]. According to the European Thyroid Association Guidelines (EU-TIRADS), nodules with no high-risk features (oval-shaped, isoechoic/hyperechoic with smooth margins) should be considered at low risk and FNA performed only if greater than 20 mm, while high-risk nodules greater than 10 mm should undergo FNAC, with possible FNAC also in 5-10 mm nodules if highly suspicious [3].

Enrollment: 86 patients

Sex: All

Ages: 15 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Thyroid diseases
• Multi nodullar
• single nodules
• diffuse goiter
• Thyroid diseases underwent FNAC Then Thyroid surgery

Exclusion criteria

• Patients with no diagnostic FNAC

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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86 participants in 2 patient groups

FNAC

Experimental group

Treatment:

Procedure: Fine Needle Aspiration Cytology

post operative hitopathology

Experimental group

Treatment:

Procedure: Fine Needle Aspiration Cytology