Accuracy of Pulse Pressure Variation and of Pleth Variability Index to Predict the Response to a Fluid Challenge (Nexfin2)

Hopital Foch

Status: Completed

Conditions: Fluid Responsiveness

Treatments: Device: - Nexfin (Pulse Pressure Variation) - Radical 7 (Pleth Variability Index) - CardioQ (stroke volume)

Study type: Interventional

Funder types: Other

Identifiers

NCT02040948

2011/56

2011-A01294-37 (Other Identifier)

Details and patient eligibility

About

The aim of this study is to compare the accuracy of Pleth Variability Index (Radical 7 device) and of Pulse Pressure Variation (Nexfin device) with the Doppler measurement of stroke volume (esophageal Doppler) to detect the response to a fluid challenge.

Enrollment: 68 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing major abdominal surgical procedures performed by laparotomy
• patients undergoing major urological surgical procedures performed by laparotomy
• patients undergoing major gynecological surgical procedures performed by laparotomy
• age ≥ 18 years
• signed informed consent

Exclusion criteria

• pregnant women
• esophageal disease
• aortic valve disease
• allergy to gelatin
• BMI > 35
• beta blocker treatment, antiarrhythmic treatment, arrhythmia, pace-maker,
• presence of an arterio-venous shunt or of any other vascular disease on upper limb

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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68 participants in 1 patient group

Surgical patients

Experimental group

Description:

* Nexfin (Pulse Pressure Variation) * Radical 7 (Pleth Variability Index) * CardioQ (stroke volume)

Treatment:

Device: - Nexfin (Pulse Pressure Variation) - Radical 7 (Pleth Variability Index) - CardioQ (stroke volume)