Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study

Mahidol University

Status: Completed

Conditions: Wheat Allergy

Treatments: Other: Commercial extract and in-house wheat extract

Study type: Interventional

Funder types: Other

Identifiers

NCT01070368

231/2552(EC4)

Details and patient eligibility

About

Nowadays, commercial wheat extract is widely accessible, and is used for skin prick test for wheat allergy. However, commercial wheat extracted for skin prick test have less precise test result compared to extract from omega-5 gliadin, which is one of the major allergen with immediate wheat allergy.

Enrollment: 30 patients

Sex: All

Ages: 1 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• A patient with the age of 1-15 year old
• A history of symptoms that suspected of type 1 hypersensitivity (eg. Urticaria, angioedema, wheezing, anaphylaxis) occur within 4 hours after wheat ingestion.
• Patients attend in allergy clinic, pediatric department, Siriraj hospital since 2007-2012

Exclusion criteria

• First sign and symptom happens more than 4 hours since wheat ingestion
• Have underlying disease such as heart disease, epilepsy etc.
• Have contraindication for performed skin prick test

Trial design

30 participants in 1 patient group

Food challenge, skin test

Experimental group

Description:

Skin test by two extract commercial, and in-house extract. and open challenge with wheat (except in patient with history of wheat anaphylaxis: assume as challenge positive)

Treatment:

Other: Commercial extract and in-house wheat extract