Accuracy of the Pleth Variability Index to Predict Fluid Responsiveness in Liver Transplantation

Inonu University

Status and phase: Completed; Phase 4

Conditions: Hemodynamic Instability

Treatments: Device: PVI-guided fluid management

Study type: Interventional

Funder types: Other

Identifiers

NCT01792011

Institute of LLT

Details and patient eligibility

About

The aim of this study is to compare the accuracy of PVI (pleth variability index)

Full description

The aim of this study is to compare the accuracy of PVI (pleth variability index)with other hemodynamic variability that measured with PİCCO (SVV, PPV, CVP,CI)to predict the response of cardiac index to volume replacement in patients undergoing liver transplantation.

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective living donor liver transplantation,
• >18 years patients

Exclusion criteria

Patients with:

• Arrhythmia
• Reduced left ventricular function (EF<40%)
• Hepatocellular carcinoma
• Pulmonary hypertension
• Fulminant liver failure
• valvular heart disease

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

---

25 participants in 1 patient group

PVI

Experimental group

Description:

A new non-invasive device (Radical-7 pulse oximeter monitor, Masimo Corp.) has been introduced that continuously detects changes in the plethysmograph waveform and computes a Plethysmography Variability Index (PVI) reflecting alteration in preload and fluid management.

Treatment:

Device: PVI-guided fluid management