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Achalasia and Dysplasia

C

Catholic University (KU) of Leuven

Status

Enrolling

Conditions

Dysplasia in Longstanding Achalasia
Relation Between Food Stasis and Dysplasia

Treatments

Other: chromoendoscopy

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Patient with achalasia have a 10-50 fold increased risk to develop esophageal squamous cell carcinoma (ESCC). Early diagnosis of ESCC is essential, and detection of an earlier dysplastic stage is preferred. Endoscopic detection is however difficult and often delayed. Chromoendoscopy with Lugol dye increases detection rates dysplasia and ESCC to 91-100%. The aim of this study was therefore to evaluate a screening program using chromoendoscopy with Lugol to detect dysplasia in patients with idiopathic achalasia.

A second objective is to study the relationship between foodstasis and the development op dysplasia

Enrollment

80 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • longstanding achalasia (> 15y)
  • > 18y old
  • informed consent

Exclusion criteria

  • allergy to iodine
  • esophageal carcinoma

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

80 participants in 1 patient group

longstanding achalasia
Experimental group
Treatment:
Other: chromoendoscopy

Trial contacts and locations

1

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Central trial contact

an moonen, MD

Data sourced from clinicaltrials.gov

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