Achalasia and Dysplasia

Catholic University (KU) of Leuven

Status: Enrolling

Conditions: Dysplasia in Longstanding Achalasia; Relation Between Food Stasis and Dysplasia

Treatments: Other: chromoendoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT02010983

S55021

Details and patient eligibility

About

Patient with achalasia have a 10-50 fold increased risk to develop esophageal squamous cell carcinoma (ESCC). Early diagnosis of ESCC is essential, and detection of an earlier dysplastic stage is preferred. Endoscopic detection is however difficult and often delayed. Chromoendoscopy with Lugol dye increases detection rates dysplasia and ESCC to 91-100%. The aim of this study was therefore to evaluate a screening program using chromoendoscopy with Lugol to detect dysplasia in patients with idiopathic achalasia.

A second objective is to study the relationship between foodstasis and the development op dysplasia

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• longstanding achalasia (> 15y)
• > 18y old
• informed consent

Exclusion criteria

• allergy to iodine
• esophageal carcinoma

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 1 patient group

longstanding achalasia

Experimental group

Treatment:

Other: chromoendoscopy