Acoustic Resonance Therapy for Treating Empty Nose Syndrome

Stanford University

Status: Begins enrollment in a year or more

Conditions: Nasal Obstruction; Empty Nose Syndrome

Treatments: Device: Personalized ART; Device: Non-personalized ART

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07215013

JN-ENT-R01

Details and patient eligibility

About

This study is to determine whether Acoustic Resonance Therapy (ART), an FDA-approved treatment for standard nasal obstruction, may be helpful in mitigating the debilitating symptoms of Empty Nose Syndrome (ENS), which includes an alternative form of nasal obstruction. ART is a non-invasive treatment that uses sound vibrations to improve nasal congestion and other sinus symptoms. ART works by delivering specific frequencies of sound to the sinonasal cavities (nose and sinuses). These vibrations cause the tissues in the sinuses to resonate, which can help break up mucus and clear blockages, reduce inflammation, and improve airflow.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Documented case of Empty Nose Syndrome
• Documented past turbinate reduction surgery

Exclusion criteria

• Neurocognitive diagnosis/decline

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Personalized ART

Experimental group

Description:

Participants receive personalized ART three times a day for 15 minutes over the study duration.

Treatment:

Device: Personalized ART

Non-personalized ART

Active Comparator group

Description:

Participants receive non-personalized ART three times a day for 15 minutes over the study duration.

Treatment:

Device: Non-personalized ART