Acquired Epidermodysplasia Verruciformis (EV) Syndrome in HIV-infected Pediatric Patients

University of Pennsylvania

Status: Completed

Conditions: Flat Warts; HIV

Treatments: Drug: Glycolic acid

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01289171

P30AI045008 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Many human immunodeficiency virus (HIV)-positive children are afflicted with diffuse flat warts that have been recalcitrant to multiple treatments.The aim of this prospective study was to evaluate the efficacy, safety and tolerability of 15% glycolic acid lotion (NeoStrata) for treatment of flat warts in HIV-positive children in Botswana. Additionally, the investigators characterized the flat warts in this population, including Human Papillomavirus (HPV) type(s) and degree of immunosuppression within the patients.

Enrollment: 38 patients

Sex: All

Ages: 7+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male or female HIV-positive patients 7 years of age or older with at least 15 flat warts, diagnosed clinically by one dermatologist (RLM), on the face and/or dorsal hands were included in the study.

Exclusion criteria

• Key exclusion criteria included current use of potential wart treatments or other topical OTC products on the affected area(s).

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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38 participants in 1 patient group

Glycolic acid

Experimental group

Description:

All who met the study criteria commenced once daily use of 15% glycolic acid lotion.

Treatment:

Drug: Glycolic acid