Acquired Von Willebrand Syndrome in Severe Aortic Stenosis

University Hospital Basel

Status: Completed

Conditions: Von Willebrand Disease; Aortic Stenosis; Bleeding

Study type: Observational

Funder types: Other

Identifiers

NCT00805051

07/08

Details and patient eligibility

About

Patients with severe aortic stenosis often suffer from an acquired Von Willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences. We hypothesized that the diagnosis of acquired von Willebrand syndrome influence perioperative blood loss in patients undergoing open cardiac valve replacement.

Full description

Patients with severe aortic stenosis often suffer from an acquired Von Willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences. After written consent and an extended anamnesis of existing coagulopathy, we take three blood samples in these patients: before surgery, on the day after surgery and 4 weeks after surgery. We determine von Willebrand factor in lab and by a point-of-care platelet function analyzer (Multiplate TM). We measure amount of mediastinal drainage after 24 hours and blood product consumption in these patients.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Severe aortic stenosis (Orifice area < 1 cm2)

Exclusion criteria

• missing consent
• severe hepatic or renal disfunction

Trial design

60 participants in 1 patient group

Severe aortic stenosis

Description:

Patients undergoing aortic valve replacement because of severe aortic stenosis