Actinium 225 Labeled Anti-CEA Antibody (Ac225-DOTA-M5A) for the Treatment of CEA Producing Advanced or Metastatic Cancers

City of Hope

Status and phase

Enrolling

Phase 1

Conditions

Metastatic Cancer

Advanced Cancer

Treatments

Drug: Actinium Ac 225-DOTA-anti-CEA Monoclonal Antibody M5A

Procedure: Biospecimen Collection

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT05204147

P30CA033572 (U.S. NIH Grant/Contract)

NCI-2021-14101 (Registry Identifier)

20449 (Other Identifier)

Details and patient eligibility

About

This phase I study tests the safety, side effects, and best dose of Ac225-DOTA-M5A in treating patients with CEA positive colorectal cancer that has spread to other places in the body (advanced). Ac225-DOTA-M5A is a humanized monoclonal anti-CEA antibody, linked to a radioactive agent called actinium 225. M5A attaches to CEA positive cancer cells in a targeted way and delivers actinium 225 to kill them.

Full description

PRIMARY OBJECTIVE:

I. To establish the maximum tolerated dose (MTD) of actinium Ac 225-DOTA-anti-CEA Monoclonal Antibody M5A (225Ac-DOTA-M5A) humanized anti-carcinoembryonic antigen (CEA) antibody when given intravenously and to describe the toxicities at each dose studied.

SECONDARY OBJECTIVES:

I. To begin to evaluate the clinical activity of the agent in metastatic colorectal cancer.

II. To evaluate the organ biodistribution, pharmacokinetics and organ dose estimates of 225Ac-DOTA-M5A.

OUTLINE: This is a dose-escalation study.

Patients receive Ac225-DOTA-M5A intravenously (IV) over 25 minutes on day 1.

After completion of study treatment, patients are followed weekly for 6-10 weeks, and then medical records are reviewed for 6 months.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients must have a histologic diagnosis of a malignancy that expresses CEA. If biopsies were performed at an outside facility, the histology must be reviewed and confirmed by the Department of Pathology at the City of Hope
Patients must have tumors that produce CEA as documented by either an elevated serum CEA above the institutional limit of normal or by immunohistochemical methods. Positive CEA immunohistochemical staining, for the purposes of this protocol, is graded 0-3 and the percentage of tumor cells positive is estimated. A positive CEA stain is determined if more than 30% of the tumor cells have an intensity of 2+ or greater
Patients must have an advanced disease for which no standard or effective treatment is available. Patients who refuse a standard but non-curative treatment is available may also be considered
Karnofsky performance status >= 60% and an estimated survival of at least 3 months
Patients must be >= 18 years old as phase I data for the antibody is not available for younger patients.
The effects of Ac-225-DOTA-M5A on the developing fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately
Adequate bone marrow function as evidenced by white blood count (WBC) >= 4000/ul, absolute neutrophil count >= 1500/ul, platelet count >= 125,000/ul are required
Adequate renal function as evidenced by a creatinine =< 1.5 mg/dl and/or a calculated creatinine clearance >= 60 cc/min
Adequate liver function as evidenced by bilirubin =< 1.5 mg/dl and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) no greater than 2 times the upper limit of normal. Less than 1/3 of the liver must be estimated to be involved with tumor
Presence of measurable disease is required for study entry
All patients must be seen in consultation by City of Hope Radiation Oncology and City of Hope Medical Oncology prior to entry onto this trial
All subjects must have the ability to understand and the willingness to sign a written informed consent
Prior radiotherapy, immunotherapy, or chemotherapy must have been completed at least 4 weeks prior to patient entry on this study (6 weeks if treated with mitomycin-c or nitrosoureas) and patients must have recovered from any expected side effects of prior therapy

Exclusion criteria

Patients should not have any uncontrolled illness including ongoing or uncontrolled active infection
Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
Pregnant women are excluded from this study because Ac225-DOTA-M5A are agents with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with Ac225-DOTA-M5A, breastfeeding should be discontinued if the mother is treated with Ac225-DOTA-M5A
Patients with recurrent or progressive brain or leptomeningeal involvement with cancer. Patients that have had previous therapies for brain metastasis or leptomeningeal disease with demonstrated response or stable disease at least four weeks after therapy will be eligible for the trial
Patients who have received previous radiation to > 50% of their bone marrow
Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study