Action of Caffeinated and Decaffeinated Espresso on Autonomic Function

Charité University Medicine Berlin

Status: Terminated

Conditions: Influence of Espresso on Heart Rate Variability

Treatments: Other: hab cof with caf espresso; Other: hab cof with water; Other: hab cof with dec espresso; Other: non-hab cof with caf espresso; Other: non-hab cof with dec espresso; Other: non-hab cof with water

Study type: Interventional

Funder types: Other

Identifiers

NCT00576030

EA4/061/06

Details and patient eligibility

About

More than 80% of the population in the USA consume coffee each day. However there not many studies on change of heart rate variability and placebo effects after consumption of coffee.

In our study we aim to test the following hypotheses:

1. Habitual caffeinated espresso coffee drinkers show an increase in blood pressure, heart rate variability and parasympathetic activity (high frequency band) of the heart.
2. Non-habitual caffeinated espresso coffee drinkers show an increase of blood pressure. The heart rate variability and the parasympathetic activity of the heart will decrease.
3. Caffeinated or decaffeinated espresso induces comparable changes in habitual or non-habitual coffee drinkers.

Enrollment: 77 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18- 50 years old, healthy

Exclusion criteria

• Medication, obese(BMI > 30)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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77 participants in 2 patient groups

H

Other group

Description:

habitual coffee drinkers

Treatment:

Other: hab cof with caf espresso

Other: hab cof with water

Other: hab cof with dec espresso

N

Other group

Description:

non-habitual coffee drinkers

Treatment:

Other: non-hab cof with dec espresso

Other: non-hab cof with water

Other: non-hab cof with caf espresso