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Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)

A

Aalborg University

Status

Completed

Conditions

Hypertonic Saline
Isotonic Saline

Treatments

Other: Saline injection
Procedure: Blood sampling
Other: hypertonic saline

Study type

Interventional

Funder types

Other

Identifiers

NCT04439994
N-20200015

Details and patient eligibility

About

In this experiment, the investigators would like to test the following:

  1. Does acute pain induced by hypertonic injection cause changes in plasma miRNA and protein expression ?
  2. Can these canges correlate with the development of local hyperalgesia?
  3. How does the plasma miRNA expression change over a duration of 24 hours post pain induction ?
  4. Which mRNA targets are potentially affected by acute pain?

Enrollment

20 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy men and women in the age 18-80 years
  • Speak and understand English

Exclusion criteria

  • Acute and chronic pain
  • Pregnancy or breastfeeding
  • Drug addiction defined as the use of cannabis, opioids or other drugs
  • Present or previous history of neurological, dermatological, immunological, musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. Neuropathy, muscular pain in the upper extremities, etc.)
  • Lack of ability to cooperate
  • Current use of medications that may affect the trial, such as antipsychotics and pain killers as well as systemic or topical steroids and anti-inflammatory drugs.
  • Skin diseases
  • Consumption of alcohol or painkillers 24 hours before the study days and between these
  • Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

20 participants in 2 patient groups, including a placebo group

Hypertonic saline
Active Comparator group
Description:
Each participant will be given i.d. in 0.1 mL volumes of a hypertonic saline solution. The subject will be blinded to the hypertonic/isotonic administration.
Treatment:
Procedure: Blood sampling
Other: hypertonic saline
Isotonic Saline
Placebo Comparator group
Description:
Each participant will be given i.d. in 0.1 mL volumes of a isotonic saline solution. The subject will be blinded to the hypertonic/isotonic administration.
Treatment:
Other: Saline injection
Procedure: Blood sampling

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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