Active Bathing to Eliminate Infection (ABATE Infection) Trial

University of California Irvine (UCI)

Status: Completed

Conditions: Multi Drug Resistant Organisms; Healthcare Associated Infections; Methicillin Resistant Staphylococcus Aureus

Treatments: Drug: Arm 2: Decolonization

Study type: Interventional

Funder types: Other; Other U.S. Federal agency; NIH

Identifiers

NCT02063867

367981

UH3AI113337 (U.S. NIH Grant/Contract)

UH2AT007769 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The ABATE Infection Project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. The two strategies to be evaluated are:

• Arm 1: Routine Care Routine policy for showering/bathing
• Arm 2: Decolonization Use of chlorhexidine as routine soap for showering or bed bathing for all patients Mupirocin x 5 days if MRSA+ by history, culture, or screen

Note that enrolled "subjects" represents 53 individual HCA Hospitals (representing ~190 non-critical care units) that have been randomized.

Enrollment: 53 patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All HCA hospitals that reside in the United States
• Note: Unit of randomization is the hospital, but the participants are hospital units

Exclusion criteria

• Non-critical care units where chlorhexidine bathing or decolonization for MRSA+ non-critical care patients is routine
• Pediatric, peri-partum, rehabilitation, psychiatry, and BMT units
• Units with >30% cardiac or hip/knee orthopedic surgeries
• Unit average length of stay <2 days
• Patients <12 years-old
• Patients with known allergy to mupirocin or chlorhexidine

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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53 participants in 2 patient groups

Arm 1: Usual Care

No Intervention group

Description:

Routine policy for showering or bathing non-critical care patients

Arm 2: Decolonization

Active Comparator group

Description:

Daily chlorhexidine (CHG) shower or CHG cloth bath for all non-critical care patients. Topical intranasal mupirocin ointment (bilateral nares, twice daily) x5 days if non-critical care patients are MRSA+ by history, culture, or screen.

Treatment:

Drug: Arm 2: Decolonization