Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease

Aydin Adnan Menderes University

Status: Completed

Conditions: Periodontal Diseases

Treatments: Diagnostic Test: GCF collection with aMMP-8 chair side test; Other: Saliva collection

Study type: Observational

Funder types: Other

Identifiers

NCT03527901

BAP-17/1

Details and patient eligibility

About

The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP-8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)

Full description

MMP-8 has been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. A positive aMMP-8 test could be an early indicator of these excessive and undesired tissue reactions.

Enrollment: 103 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Systemically healthy
• Nonsmokers

Exclusion criteria

• Participants were not included if they had systemic disease such as diabetes, cardiovascular.
• Participants who took regular medications that could affect of periodontal tissue
• Participants who received antibiotics less than 10 weeks before the study

Trial design

103 participants in 5 patient groups

Chronic periodontitis

Description:

This groups participant has radiographically moderate alveolar bone loss, CAL > 5 mm and PD >6 mm in several sites of each quadrant

Treatment:

Other: Saliva collection

Diagnostic Test: GCF collection with aMMP-8 chair side test

Generalized aggressive periodontitis

Description:

This demonstrated a generalized pattern of severe breakdown and CAL > 5 mm and PD > 6 mm on 8 > teeth; minimum three of those were other than first incisors or first molars

Treatment:

Other: Saliva collection

Diagnostic Test: GCF collection with aMMP-8 chair side test

Gingivitis

Description:

This group has varying degrees of gingival inflammation, with CAL < 2 mm, without any radiographical bone loss due to periodontitis

Treatment:

Other: Saliva collection

Diagnostic Test: GCF collection with aMMP-8 chair side test

Implant

Description:

Implants classified PD < 5 mm, no bleeding on probing, no suppuration and no radiographic bone loss > 0.5 mm

Treatment:

Other: Saliva collection

Diagnostic Test: GCF collection with aMMP-8 chair side test

Health

Description:

Probing depth (PD) < 3mm, no gingival recession due to periodontal disease, and clinical attachment level (CAL) < 2 mm, BOP in < 10% of full-mouth score examination

Treatment:

Other: Saliva collection

Diagnostic Test: GCF collection with aMMP-8 chair side test