Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease

A

Aydin Adnan Menderes University

Status

Completed

Conditions

Periodontal Diseases

Treatments

Diagnostic Test: GCF collection with aMMP-8 chair side test
Other: Saliva collection

Study type

Observational

Funder types

Other

Identifiers

NCT03527901
BAP-17/1

Details and patient eligibility

About

The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP-8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)

Full description

MMP-8 has been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. A positive aMMP-8 test could be an early indicator of these excessive and undesired tissue reactions.

Enrollment

103 patients

Sex

All

Ages

20 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Systemically healthy
  • Nonsmokers

Exclusion criteria

  • Participants were not included if they had systemic disease such as diabetes, cardiovascular.
  • Participants who took regular medications that could affect of periodontal tissue
  • Participants who received antibiotics less than 10 weeks before the study

Trial design

103 participants in 5 patient groups

Chronic periodontitis
Description:
This groups participant has radiographically moderate alveolar bone loss, CAL > 5 mm and PD >6 mm in several sites of each quadrant
Treatment:
Other: Saliva collection
Diagnostic Test: GCF collection with aMMP-8 chair side test
Generalized aggressive periodontitis
Description:
This demonstrated a generalized pattern of severe breakdown and CAL > 5 mm and PD > 6 mm on 8 > teeth; minimum three of those were other than first incisors or first molars
Treatment:
Other: Saliva collection
Diagnostic Test: GCF collection with aMMP-8 chair side test
Gingivitis
Description:
This group has varying degrees of gingival inflammation, with CAL < 2 mm, without any radiographical bone loss due to periodontitis
Treatment:
Other: Saliva collection
Diagnostic Test: GCF collection with aMMP-8 chair side test
Implant
Description:
Implants classified PD < 5 mm, no bleeding on probing, no suppuration and no radiographic bone loss > 0.5 mm
Treatment:
Other: Saliva collection
Diagnostic Test: GCF collection with aMMP-8 chair side test
Health
Description:
Probing depth (PD) < 3mm, no gingival recession due to periodontal disease, and clinical attachment level (CAL) < 2 mm, BOP in < 10% of full-mouth score examination
Treatment:
Other: Saliva collection
Diagnostic Test: GCF collection with aMMP-8 chair side test

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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