Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients

Fudan University

Status: Enrolling

Conditions: Tuberculosis; Latent Tuberculosis Infection

Treatments: Diagnostic Test: QuantiFERON-TB Gold (QFT) test

Study type: Observational

Funder types: Other

Identifiers

NCT06033807

TB-Youth Screening

Details and patient eligibility

About

The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are:

• the proportion of MTB infection among school contacts of ATB patients
• risk factors related to tuberculosis (TB) infection
• health economic evaluation of screening strategy

Enrollment: 31,440 estimated patients

Sex: All

Ages: 13+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 13 years old or above;
• Students in junior middle school, high school and university;
• Close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory);
• Himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign informed consent.

Exclusion criteria

• Current clinical or sputum culture confirmed active tuberculosis
• Have completed a full course of treatment for ATB or LTBI

Trial design

31,440 participants in 1 patient group

Contacts

Description:

School contacts of ATB patients

Treatment:

Diagnostic Test: QuantiFERON-TB Gold (QFT) test