Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome (PCOSLFEA)

Göteborg University

Status

Completed

Conditions

Polycystic Ovary Syndrome

Treatments

Other: Meeting a therapist - attention control

Device: Low-frequency electro-acupuncture (EA)

Study type

Interventional

Funder types

Other

Identifiers

NCT00921492

ALFFGBG-10984

PCOSLFEA-17611

2008-72VP-15445-01A

Details and patient eligibility

About

Hypothesis The overall hypothesis is that non-obese (BMI <30) women with PCOS have high luteinising hormone (LH) and cortisol pulse frequency and amplitude and that repeated low-frequency EA restore these alterations and induce ovulation.

Full description

Aim 1. Elucidate if low-frequency EA induce ovulation and restore LH frequency and amplitude as well as sex steroid secretion as compared to a control group receiving same amount of attention.

Aim 2. Elucidate if low-frequency EA restore cortisol frequency and amplitude compared to a control group receiving same amount of attention.

Aim 3. Elucidate if low-frequency EA restore psychological distress and quality of life as compared to a control group receiving same amount of attention.in women with PCOS.

Enrollment

28 patients

Sex

Female

Ages

18 to 39 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

18 - 39 years, inclusive
30 ≤ BMI
History of irregular menstrual cycles
Clinical and/or biochemical androgen excess (determined during screening)

Exclusion criteria

Medical Exclusion Criteria

History or clinical manifestation of; cardiovascular disease, diabetes (Type 1 or Type 2), any other significant endocrine or metabolic disorder.
Regular use of medications for weight control, psychosis and thyroid disease. A 3 month washout period will be permitted for contraceptives.

Psychiatric and Behavioral Exclusion Criteria