Acupuncture for Chemotherapy-induced Peripheral Neuropathy

Pusan National University

Status

Unknown

Conditions

Peripheral Neuropathy

Multiple Myeloma

Lymphoma

Toxicity Due to Chemotherapy

Treatments

Procedure: Acupuncture

Study type

Interventional

Funder types

Other

Identifiers

NCT01892852

AcuCIPN

Details and patient eligibility

About

The purpose of this study is to evaluate whether acupuncture can be effective for chemotherapy-induced peripheral neuropathy in lymphoma or multiple myeloma patients.

Enrollment

36 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

At least 18 years of age and have diagnosis of a lymphoma or multiple myeloma.
Patients must have chemotherapy-induced peripheral neuropathy greater or equal to 2 according to CTCAE (Common Terminology Criteria for Adverse Events) v 3.0 scale (Appendix A) in spite of previous conventional medications, e.g. Neurontin, Cymbalta and/or Lyrica. Patients receiving any of conventional medication for this symptoms must remain on the same medications throughout the study period.
Patients, or the legal guardians of patients, must have the ability to understand Korean, and be ble to provide informed consent.
ECOG (Eastern Cooperative Oncology Group) Performance Status of 0, 1, or 2.
If the patient is a woman of child-bearing potential, she must have a negative urine pregnancy test and agree to use contraception.

Exclusion criteria

Other diseases that, in the opinion of the investigators, can cause peripheral neuropathy, such as alcoholism, diabetes mellitus, and HIV.
Current active treatment for lymphoma or multiple myeloma
Ongoing local infection at or near the acupuncture point adopted in this trial.
Severe immunocompromised patients, leukopenia ( < 4,000/㎣) or neutropenia ( < 1,500/㎣)
Known coagulopathy, thrombocytopenia (< 50,000/㎣), and taking heparin (including low molecular weight heparin) or Coumadin at any dose.
Serious emotional or mental problems that precludes study entry.
Mental and physical disability that precludes accurate acupuncture.
Serious systemic diseases such as active infection, severe heart disease, uncontrolled hypertension and diabetes mellitus.
Cardiac pacemaker.
Pregnant or breastfeeding
Acupuncture therapy within the previous 30 days
Concurrent other complementary and alternative therapy such as herbal agents, high dose vitamins, and etc.