Acute Cerebrovascular Events in Patients Undergoing Catheter Ablation (CENTRAL)

Xi'an Jiaotong University

Status: Not yet enrolling

Conditions: Arrhythmia; Acute Cerebrovascular Disease

Treatments: Procedure: Radiofrequency catheter ablation

Study type: Observational

Funder types: Other

Identifiers

NCT05694273

XJTU1AF2023LSK-531

Details and patient eligibility

About

This study aims to evaluate the incidence, clinical characteristics, and short-term prognosis of acute cerebrovascular events occurring in-hospital in patients with arrhythmias following catheter ablation. The goal is to provide evidence supporting the improvement of patient quality of life and reduction of in-hospital acute cerebrovascular complications in patients with post-ablation arrhythmias. This will also contribute to the evidence-based clinical management of such patients.

Full description

With the steady development of catheter ablation, it has gradually become the main treatment of various arrhythmias. Antithrombotic and anticoagulant therapy after catheter ablation determines the occurrence of perioperative bleeding and ischemic events. However, the incidence, characteristics and short-term prognosis of secondary acute cerebrovascular events in patients with arrhythmia after catheter ablation have not been studied. Methods: This study was intended to retrospectively collect and analyze the case data and auxiliary examination results of patients with arrhythmia who underwent catheter ablation. To evaluate the incidence, clinical features and short-term prognosis of secondary acute ischemic and hemorrhagic cerebrovascular events in patients with arrhythmia after catheter ablation. In order to improve the quality of life of patients, reduce the secondary acute cerebrovascular complications in the hospital in patients with arrhythmia after catheter ablation, to provide evidence for promoting the clinical management of such patients, and to provide help for the maximum degree of prevention and control risk.

Enrollment: 2,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1.Patients who undergo catheter ablation for arrhythmias.

Exclusion criteria

• 1. Patients were diagnosed of acute cerebrovascular disease prior to radiofrequency catheter ablation;
• 2. Patients < 18 years or > 80 years;
• 3. Patients with uncomplete clinical data.

Trial design

2,000 participants in 4 patient groups

Ischemic stroke group

Description:

1. Ischemic stroke secondary to patients receiving catheter ablation. 2. Ischemic stroke met the diagnostic criteria of the 2018 edition of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke, and was confirmed by cranial CT/MRI scan.

Transient ischemic attack group

Description:

1. Transient ischemic attack secondary to patients receiving catheter ablation. 2. Ischemic stroke met the diagnostic criteria of the 2018 edition of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke, and was confirmed negative of new onset of infarction by cranial CT/MRI scan.

Cerebral hemorrhage group

Description:

1. Cerebral hemorrhage secondary to patients receiving catheter ablation. 2. Cerebral hemorrhage met the diagnostic criteria of the 2021 Chinese Guidelines for the Diagnosis and Treatment of cerebral hemorrhage and was confirmed by head CT/MRI.

Contral group

Description:

Patients who did not experience acute cerebrovascular events in the hospital.