Acute Coronary Disease (ACS)- Strain (ACS-Strain)

RWTH Aachen University

Status: Completed

Conditions: Cardiac and Non Cardiac Thoracal Disorder

Treatments: Other: retrospective echographic myocardial strain analysis refering to acute coronary syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT02357641

CTC-A 13-089

Details and patient eligibility

About

Examination of probable distinction between cardiac or non- cardiac thoracal disorder via echocardiographic myocardial strain analysis

Full description

Patients with cardiac disorder have to undergo time- consuming and expensive examinations such as laboratory of cardiac biomarkers or ischemic diagnostic. To save time and money in this observational registry the probable distinction between cardiac and non- cardiac disorder in patients with vague thoracal disorder and the probability for coronary artery disease (determined via Grace Score) is examined via echographic myocardial strain analysis in 300 patients retrospectively to establish a cut off value corresponding to acute coronary disease also to prevent coronary angiography. Therefore patients undergo echography routinely with consecutive evaluation of systolic, diastolic and strain analysis to elevate exact statements with reference to deformation of the myocard and its velocity. Several study have shown that these strain parameters (circumferential and radial strain) enable vitality and ischemic diagnosis and therefore could be eligible for this purpose.

Enrollment: 300 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• thoracal cardiac or non cardiac disorder
• signed informed consent

Exclusion criteria

• glomerular filtration rate (GFR) < 60 ml/min
• angina pectoris
• acute myocardial infarction within 3 months prior inclusion
• pregnancy

Trial design

300 participants in 1 patient group

Patients with thoracal disorder

Description:

300 patients with thoracal disorder, cardiac or non- cardiac, are enrolled prospectively to undergo routinely examinations such as clinical and hemodynamic chemistry as well as echocardiography for strain analysis refering to myocardial deformation. Especially analysis of strain data (circumferential and radial), regional and global left and right ventricular wall movement data and diastolic parameters will be analysed retrospectively to investigate a probable cut off value corresponding to acute coronary disease or non cardiac disorder (Intervention: retrospective echographic myocardial strain analysis refering to acute coronary syndrome).

Treatment:

Other: retrospective echographic myocardial strain analysis refering to acute coronary syndrome