Acute Dietary Nitrate in Dilated Cardiomyopathy

Royal College of Surgeons, Ireland

Status: Completed

Conditions: Cardiomyopathy

Treatments: Dietary Supplement: Dietary nitrate; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02471417

Acute NO3- in DCM

Details and patient eligibility

About

Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD. Many patients with dilated cardiomyopathy have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in dilated cardiomyopathy subjects compared to a placebo beetroot juice.

Full description

Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD. Many patients with dilated cardiomyopathy have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in dilated cardiomyopathy subjects compared to a placebo beetroot juice. This study is a randomized, double-blind placebo-controlled, crossover trial. Resting blood pressure, phlebotomy and ISWT will be performed. Following completion, each subject is randomized to consume beetroot juice or placebo. 3 hours later, the same assessments are repeated by the same people. After a 7d washout, the entire protocol is repeated with the crossover beverage.

Enrollment: 12 patients

Sex

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinically stable,
• Confirmed non-ischemic, dilated cardiomyopathy

Exclusion criteria

• Active musculo-skeletal conditions
• Ischemic heart disease
• Pulmonary hypertension
• COPD
• Taking vasodilators
• Diabetes mellitus

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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12 participants in 2 patient groups, including a placebo group

Nitrate rich beetroot juice

Experimental group

Description:

Concentrated, beetroot juice is a rich source of dietary nitrate.

Treatment:

Dietary Supplement: Dietary nitrate

Nitrate depleted placebo beetroot juice

Placebo Comparator group

Description:

Placebo beetroot juice is identical to active beetroot juice in every way except nitrate content.

Treatment:

Dietary Supplement: Placebo