Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects (Ang-(1-7))

Instituto de Cardiologia do Rio Grande do Sul

Status and phase: Unknown; Early Phase 1

Conditions: Hypertension

Treatments: Drug: Angiotensin 1-7; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03001271

4576/10

Details and patient eligibility

About

In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II. The aim is to evaluate the effect of Ang-(1-7) acute administration on systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in healthy and hypertensive subjects.

Enrollment: 32 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Healthy Group Inclusion Criteria:

• arterial pressure <140/90 mmHg
• body mass index (BMI) between 18,5 and 29 Kg/m2

Hypertensive Group Inclusion Criteria:

• anti-hypertensive drug treatment
• ambulatory blood pressure monitoring (ABMP) >130/85 mmHg
• body mass index between 18,5 and 29 Kg/m2

Healthy Group Exclusion Criteria:

• drug treatment
• recent surgeries
• pregnancy
• previous cardiovascular events
• high performance athletes
• dislipidemia
• diabetes
• renal injury
• obesity (BMI above 30 kg/m2)
• alcoholism
• smoking.

Hypertensive Group Exclusion Criteria:

• recent surgeries
• pregnancy
• beta-blockers drug treatment
• previous cardiovascular events
• high performance athletes
• dislipidemia
• diabetes
• renal injury
• obesity (BMI above 30 kg/m2)
• alcoholism
• smoking

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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32 participants in 2 patient groups

Healthy Subjects

Experimental group

Description:

Placebo and Angiotensin-(1-7) acute infusion

Treatment:

Other: Placebo

Drug: Angiotensin 1-7

Hypertensive Subjects

Experimental group

Description:

Placebo and Angiotensin-(1-7) acute infusion

Treatment:

Other: Placebo

Drug: Angiotensin 1-7