Acute Effect of Crocus Sativus on Postprandial Glycemia

Agricultural University of Athens

Status: Completed

Conditions: Appetitive Behavior; Potential Abnormality of Glucose Tolerance; Blood Pressure

Treatments: Other: D-Glucose beverage as reference food; Other: 15mg of Crocus Sativus as beverage; Other: 30mg of Crocus Sativus as beverage

Study type: Interventional

Funder types: Other

Identifiers

NCT05484362

HRBD 58/21.06.2022

Details and patient eligibility

About

This study investigated the effects of two different doses of Crocus Sativus in glucose beverages on glycemic responses.

Full description

This study examined the short-term effects of two different doses (15 mg and 30 mg) of Crocus Sativus in glucose beverages on postprandial glycemic responses in healthy young adults.

Enrollment: 11 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Non-smoking
• Non-diabetic men and women
• Body Mass Index (BMI) between 18.5 and 24.9 kg/m2
• Normal blood pressure

Exclusion criteria

• Severe chronic disease (e.g., coronary heart disease, diabetes mellitus, kidney or liver conditions, endocrine conditions)
• Gastrointestinal disorders
• Pregnancy
• Lactation
• Competitive sports
• Alcohol abuse
• Drug dependency
• Allergy in Crocus Sativus

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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11 participants in 3 patient groups

Glucose as reference food

Experimental group

Description:

Eleven healthy subjects (male: 6, female: 5) after 10-14h fast, consumed 50 g D-glucose, three times, in different weeks along with 250 mL water; and 50 g D-glucose containing 15 mg and 30 mg of Crocus Sativus tested once, in different weeks along with 250 mL water. Fingertip capillary blood glucose samples were taken at 0, 15, 30, 45, 60, 90 and 120 min postmeal. The first glucose sample was taken exactly 15 min after the beginning of the consumption of the tested beverage.

Treatment:

Other: D-Glucose beverage as reference food

Other: 15mg of Crocus Sativus as beverage

Other: 30mg of Crocus Sativus as beverage

15mg of Crocus Sativus as beverage

Experimental group

Description:

Eleven healthy subjects (male: 6, female: 5) after 10-14h fast, consumed 50 g D-glucose, three times, in different weeks along with 250 mL water; and 50 g D-glucose containing 15 mg and 30 mg of Crocus Sativus tested once, in different weeks along with 250 mL water. Fingertip capillary blood glucose samples were taken at 0, 15, 30, 45, 60, 90 and 120 min postmeal. The first glucose sample was taken exactly 15 min after the beginning of the consumption of the tested beverage.

Treatment:

Other: D-Glucose beverage as reference food

Other: 15mg of Crocus Sativus as beverage

Other: 30mg of Crocus Sativus as beverage

30mg of Crocus Sativus as beverage

Experimental group

Description:

Eleven healthy subjects (male: 6, female: 5) after 10-14h fast, consumed 50 g D-glucose, three times, in different weeks along with 250 mL water; and 50 g D-glucose containing 15 mg and 30 mg of Crocus Sativus tested once, in different weeks along with 250 mL water. Fingertip capillary blood glucose samples were taken at 0, 15, 30, 45, 60, 90 and 120 min postmeal. The first glucose sample was taken exactly 15 min after the beginning of the consumption of the tested beverage.

Treatment:

Other: D-Glucose beverage as reference food

Other: 15mg of Crocus Sativus as beverage

Other: 30mg of Crocus Sativus as beverage