Acute Effect of Exercise on Vascular Function

University of Florida

Status: Completed

Conditions: Aging

Treatments: Device: Treadmill; Other: Interval Training; Other: Slow-paced walking; Other: Moderate-paced walking

Study type: Observational

Funder types: Other

Identifiers

NCT02408614

IRB201401078

Details and patient eligibility

About

The study objectives are the following: 1) To examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) To examine the influence of age and gender on these responses.

Full description

The type, intensity and duration of exercise, fitness state, and timing of measurements have been reported to influence the acute vascular responses to exercise. However, little is known regarding the influence of interval training, aging and gender on these responses. The objectives of this study are: 1) to examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) to examine the influence of age and gender on these responses. Subjects will perform the following 3 types of treadmill exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval training. Flow mediated dilation using high resolution ultrasonography and arterial stiffness using applanation tonometry will be measured before, immediately after and 1-hour after each acute bout of exercise.

Enrollment: 69 patients

Sex: All

Ages: 18 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men and women 18 to 79 years of age
• Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
• Premenopausal women will be eumenorrheic.
• Able to give consent.

Exclusion criteria

• History of hepatic disease or infection with hepatitis B, C or HIV
• History of other relevant on-going or recurrent illness
• Recent (within 3 months) or recurrent hospitalizations
• Current intake of medications that may affect study results
• Use of tobacco products
• Premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
• Pregnancy (positive urine pregnancy test) or lactation
• Perimenopausal women

Trial design

69 participants in 3 patient groups

Slow-paced walking

Description:

Subjects will complete 47 minutes of walking at slow pace.

Treatment:

Device: Treadmill

Other: Slow-paced walking

Moderate-paced walking

Description:

Subjects will complete 47 minutes of walking at a moderate pace.

Treatment:

Device: Treadmill

Other: Moderate-paced walking

Interval training

Description:

Subjects will complete 40 minutes of walking alternating between a moderate and fast pace.

Treatment:

Other: Interval Training

Device: Treadmill