Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Regional Hospital Holstebro

Status and phase: Completed; Phase 4

Conditions: Healthy

Treatments: Drug: HMG-CoA reductase inhibition (atorvastatin)

Study type: Interventional

Funder types: Other

Identifiers

NCT00344955

MED.RES.HOS.2004.01.LP

Details and patient eligibility

About

We wanted to test the acute effect of HMG-CoA reductase inhibition (atorvastatin) on renal hemodynamics, renal tubular function and vasoactive hormones on healthy subjects.

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Both men and women
• Age: Between 20-50
• BMI<30

Exclusion criteria

• Clinical signs or history of disease of heart, lungs, kidneys or endocrine organs.
• Abnormal lab. tests( haemoglobin, pl. sodium, pl. potassium, pl.creatinine, pl.bilirubin, pl.ALAT, pl. cholesterol, blood glucose)
• Albuminuria or glucosuria
• Cancer
• Art. hypertension
• Alcohol abuse
• Medical treatment, except oral contraceptives
• Pregnancy or breast feeding
• Blood donation less than 1 month before study