Acute Effect of modeRate-intensity aerOBIc Exercise on Colon Cancer Cell Growth (AEROBIC)

Northumbria University

Status: Unknown

Conditions: Colon Cancer; Colon Adenocarcinoma

Treatments: Other: Exercise assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT04057274

AEROBIC2019

Details and patient eligibility

About

This study involves drawing blood samples from men before and after they perform 30-minutes of moderate-intensity aerobic exercise. The investigators will evaluate whether adding the exercise serum to colon cancer cells in a dish can reduce the growth of the cells compared to the resting serum.

Note: serum is the liquid part of the blood that carries hormones and metabolites around the body.

Full description

Regular exercise is associated with a reduced risk of developing colon cancer. However, the mechanisms underpinning the anti-cancer effect of exercise are not yet fully understood. A recent theory suggests that each time you exercise, the short-lasting spikes in circulating hormones can suppress the growth of cancer cells. Hence, every exercise bout could have a direct anti-cancer effect.

This study will recruit men with an increased of colon cancer and explore whether incubating colon cancer cells with serum collected after a bout of moderate-intensity aerobic exercise influences cell viability in vitro.

Enrollment: 16 patients

Sex: Male

Ages: 50 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥ 50 years
• BMI ≥ 25 kg/m2 and/or waist circumference of ≥ 94 cm
• Male
• Participating in less than 30 min of planned, structured, moderate to vigorous-intensity physical activity on three or more d·wk-1 for the last three months

Exclusion criteria

• Any absolute or relative contraindication to exercise testing, as determined by the American College of Sports Medicine
• Any sign/symptom of cardiovascular, metabolic or renal disease
• Known cardiovascular, metabolic or renal disease without written medical clearance from physician
• Resting hypertension (≥160 mmHg systolic and/or ≥90 mmHg diastolic)
• Chronic obstructive pulmonary disease and/or asthma with peak respiratory flow < 300 l/min
• Previous stroke or transient ischemic attack
• Epilepsy or aneurysm (large vessel or cerebral)
• Previous or current treatment for malignancy
• Clotting disorder
• Taking beta-adrenergic blocking agents
• Resting heart rate ≥ 100 bpm
• Musculoskeletal, neurological, anthropometric, or rheumatoid conditions that makes it not possible to pedal a bicycle and/or would be worsened due to exercise
• Body mass > 150 kg

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

Exercise assessment

Experimental group

Description:

The exercise condition will involve venous blood samples being drawn immediately before and after a single bout of moderate-intensity aerobic interval exercise.

Treatment:

Other: Exercise assessment

Resting assessment

No Intervention group

Description:

The resting condition will involve venous blood samples being drawn before and after 60 minutes of seated rest.