Acute Effect of Resistance Training in Inflammatory Markers in Women With Rheumatoid Arthritis

Federal University of São Paulo

Status and phase

Completed

Phase 4

Conditions

Rheumatoid Arthritis

Treatments

Other: Resistance training

Study type

Interventional

Funder types

Other

Identifiers

NCT02401958

CEP UNIFESP -

Details and patient eligibility

About

ABSTRACT Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory, chronic and progressive disease that can lead to joint destruction and important functional disability. Chronic inflammation, with a substantial increase in the amount of pro-inflammatory cytokines in synovial joint, is one of the biggest challenges in controlling RA. Resistance exercise has been recognized for positively modulate inflammation in healthy subjects. Objective: To evaluate the effect of an acute bout of resistance exercise on serum concentrations of tumor necrosis factor alpha (TNF-α), interleukin 1 receptor antagonist(IL-1ra), interleukin 1 beta (IL-1β), C reactive protein (CRP), interleukin 6 (IL-6), interleukin 10 (IL-10), and cartilage oligomeric matrix protein (COMP) in postmenopausal women with RA and women without the disease. Methods: 17 volunteers with RA and 17 without the disease, with a mean age of 54.7 + 6.63 underwent a resistance exercise session with a set of 12 repetitions at 50% of one repetition maximum (1RM ) and a set of 8 repetitions at 75% of 1RM. The exercises performed were: knee extension, knee flexion, hip abduction and hip adduction. Blood samples were obtained 30 minutes before, 5 minutes before, immediately after, 1 hour, 2 hours and 24 hours after the exercise session. Serum glucose concentrations prior to exercise were also measured. The investigators used the Student's't test, the model of analysis of variance with repeated measures and Bonferroni method of multiple comparisons to analyze the data, being considered statistically significant levels of p <0.05.

Enrollment

34 patients

Sex

Female

Ages

45 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

*Rheumatoid Arthritis Group

Inclusion Criteria:

Women classified acording to the American College of Rheumatology's criteria to rheumatoid arthritis
Post menopausal women
Stable medication three months before study

Exclusion Criteria:

Women with rheumatoid arthritis with functional class IV, acording to ACR criteria
Women engaged in some type of regular exercise program;
Failure: heart, coronary, respiratory, renal and / or hepatic (uncompensated);
Uncompensated systemic hypertension;
Volunteers with other associated inflammatory diseases;
Unable to perform the exercises.
- Control group We included in the control group of this study postmenopausal volunteers, without Rheumatoid Arthritis. Exclusion criteria were the same as those adopted for the participants of the Rheumatoid Arthritis Group