Acute Effects of a Non Excitatory Cardial Stimulation

RWTH Aachen University

Status

Completed

Conditions

CCM Implantation

Treatments

Other: Blood sample

Study type

Interventional

Funder types

Other

Identifiers

12-032

Details and patient eligibility

About

Electric stimulation by cardial contractility modulation (CCM)to improve contractility and physical capacity

Enrollment

13 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

planned CCM Implantation
systolic left ventricular dysfunction despite of adequate therapy of heart failure (NYHA II, III, IV)
implanted pacemaker, defibrillator or pacemaker during CS intubation
written informed consent
open entryways

Exclusion criteria

anemia Hemoglobin (HB)<8 mg/dl
lying coronary sinus (CS) tube or CS being not able to intubate
chronic atrial fibrillation or flutter
mechanic tricuspid valve prothesis
no access via subclavian vein
patients with VVI pacemaker being stimulated 110%
idiopathic hypertrophic cardiomyopathy, restrictive constrictive cardiomyopathy or heart failure because of known inflammatory or infiltrative illnesses or constrictive illness
acute myocardial ischemia presented by angina pectoris or ECG changes under load
patients being hospitalized because of heart failure during the last month and have to be treated with intravenous diuretics or inotropic substances
acute coronary syndrome should not be implanted for at least 3 month
patients with mechanic aortic or tricuspid valve
patients after heart transplantation
patients with clinical significant ectopy, defined by > 8.900 PVCs during 24 hours at beginning Holter monitoring
patients after hypertensive crisis
patients with acute renal failure
Ejection Fraction (EF) > 35
patients after left ventricular pacemaker electrode
pregnant or breast feeding women
patients with heart failure after sepsis