Acute Effects of Cold Exposure on Cardiovascular System

Fudan University

Status

Enrolling

Conditions

Cardiovascular System

Treatments

Other: Low temperature (15°C) group

Other: Moderate temperature (22°C) group

Study type

Interventional

Funder types

Other

Identifiers

NCT06652425

IRB#2024-10-1167

Details and patient eligibility

About

This is a randomized controlled human exposure crossover study. Investigators aim to assess the acute effects of low temperature exposure on cardiovascular system and the underlying mechanisms.

Full description

The investigators will conduct a randomized controlled human exposure crossover study among about 40 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the low temperature (15°C) and once to the moderate temperature (22°C) in a chamber for about 2 hours. During the exposure session, each subject will be requested to rest. Health examinations will be conducted at baseline immediately prior to exposure, during the period of exposure, and after exposure. Health examinations include blood pressure tests and Holter monitoring. Investigators plan to collect blood and urine samples.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Living in Shanghai during the study period;
Body mass index > 18.5 and ≤ 28;
Right-handed;
Receiving or having received higher education;
With the ability to read and understand Chinese smoothly.

Exclusion criteria

Smoking and alcohol abuse;
Current drug and dietary supplements intake;
Subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy;
Subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension;
Subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;
Subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease;
Subjects who have a history of major surgery due to cardiovascular, cerebrovascular, respiratory, or neurological diseases;
Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia;
Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1/FVC ≤ 0.65);
Subjects with color vision disabilities.