Acute Effects of Different Macronutrient Compositions and Meal Distributions of the Food (DIT2)

University Hospital, Linkoeping

Status: Unknown

Conditions: Metabolic Rate; Serum Insulin; Sense of Satiety; Plasma Glucose; Serum Triglycerides

Treatments: Other: two test meals with two different macronutrient compositions

Study type: Interventional

Funder types: Other

Identifiers

NCT02622490

DIT2

Details and patient eligibility

About

About thirty participants, of varying degrees of obesity or being non-obese, without serious concomitant diseases consume either a high- or a low- carbohydrate beverage. The beverage is also consumed either as one single drink or as 5 small portions in the morning and are tested for effects on major cardiovascular risk markers and on metabolic rate for three hours on each occasion.

Full description

Thirty participants come to the metabolic ward at about 8 o´clock in the fasting state and stay until lunch on four occasions each. The participants are randomized to the order of the test meals. The meals have a total caloric content of 750 kcal and have either 50% of energy from carbohydrates (low fat) or 20% of energy from carbohydrates (low carb.). The meals are consumed on one occasion in the morning or divided in 5 portions (150 kcal each) for every 30 minutes, i.e. total combinations of meal composition and of meal distribution is 4. Effects of the food on p-glucose, s-insulin, blood-lipids, hormones and on metabolic rate is measured by blood tests or by indirect calorimetry (for metabolic rate). Sense of satiety is measured by visual analogue scales.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy participants > 18 years with or without obesity

Exclusion criteria

• Major illnesses,
• thyroid diseases,
• need to take prednisolone,
• psychiatric disease,
• inability to understand Swedish

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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28 participants in 4 patient groups

Low carb. one meal

Active Comparator group

Description:

Intervention: One meal of 750 kcal with 20 % of energy content from carbohydrates

Treatment:

Other: two test meals with two different macronutrient compositions

Low Carb. 5 small meals

Active Comparator group

Description:

Intervention: Five meals every 30 minutes of 150 kcal/each with 20 % of energy content from carbohydrates.

Treatment:

Other: two test meals with two different macronutrient compositions

High carb. one meal

Active Comparator group

Description:

Intervention: One meal of 750 kcal with 50 % of energy content from carbohydrates

Treatment:

Other: two test meals with two different macronutrient compositions

High carb. 5 meals

Experimental group

Description:

Intervention: Five meals every 30 minutes of 150 kcal/each with 50 % of energy content from carbohydrates.

Treatment:

Other: two test meals with two different macronutrient compositions