Acute Effects of Exercise in Women With Fibromyalgia (FM)

Göteborg University

Status: Completed

Conditions: Fibromyalgia

Study type: Observational

Funder types: Other

Identifiers

NCT01592916

GU-143-12

Details and patient eligibility

About

The investigators previous studies of aerobic exercise in women with fibromyalgia (FM) have shown that exercise improves body functions and/or symptom severity in most patients, but not in all. About a third of patients with FM have been shown to have low levels of IGF-1. The purpose of this project is to study individual and biological factors that interact with outcomes of short-term (acute) exercise in FM.

Method. A controlled prospective exercise study. Thirty women with FM and 30 healthy age-matched women, aged 20-50 years, will be recruited to the study. Two 15-minute ergometer bicycle exercise tests will be conducted in feasting patients, separated by one month. The first exercise test is at a low and the second at a high intensity. Measurements comprise blood test, pain rating and pain threshold, conducted before and after the test. The levels of IGF-1, IL-6 and IL-8 will be measured, and the changes in them will be related to health status and pain.

Enrollment: 55 patients

Sex: Female

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• clinical diagnosis of fibromyalgia
• age 20-50 years

Exclusion criteria

• heart disease
• neurological disease
• severe osteoarthritis

Trial design

55 participants in 2 patient groups

Fibromyalgia

Description:

Women with fibromyalgia, aged 20-50 years

Healthy controls

Description:

Women without severe disease, aged 20-50 years