Acute Effects of Ginger Extract Consumption on Risk Markers of Cardiovascular Disease (G-CVD)

University of Reading

Status: Completed

Conditions: Cardiovascular Disease

Treatments: Dietary Supplement: Placebo: Super pure water; Dietary Supplement: Ginger drink

Study type: Interventional

Funder types: Other

Identifiers

NCT02735486

PHYTOVAS II

Details and patient eligibility

About

The primary aim of the study was to investigate the acute effect of ginger drink consumption on the risk markers of cardiovascular disease.

Full description

A randomized, single-blind human intervention study involving 22 healthy male volunteers was designed to investigate the acute effects of ginger drink consumption on risk markers of cardiovascular disease (CVD). The primary outcome measure is reduction in blood pressure while the secondary outcome measures are improvement in flow mediated dilatation (FMD) and changes in plasma biochemical profile parameters related to CVD. Participants were given 300 ml of ginger extract or water (placebo) with breakfast, followed by a lunch at 2 hours on two visits separated by 2 weeks. Blood and urine samples were collected at regular intervals as well as blood pressure measurement done during the two visits. Vascular function was measured by flow mediated dilatation (FMD) and pulse wave velocity (PWV) at baseline, 2 and 4 hours after the the consumption of the study drink and placebo. The blood and urine samples were analysed for changes in lipid profile and other markers of CVD.

Enrollment: 22 patients

Sex: Male

Ages: 30 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Apparently healthy males,
• Age (30 - 65) years,
• Not diabetic or plasma glucose > 7 or on anti-diabetic drugs and not on anti- hypertensive drugs.
• Subjects < 10% risk of cardiovascular disease

Exclusion criteria

• Women,
• Men younger than 30 years and older that 65 years,
• Men who are sick or on anti-diabetic and anti-hypertensive drugs.
• Men who have history of heart attack or stroke within the last 12 months
• Men who are on lipids lowering drugs

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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22 participants in 2 patient groups, including a placebo group

Ginger drink

Experimental group

Description:

Experimental: Ginger drink (300 ml) to be consumed during the study visit

Treatment:

Dietary Supplement: Ginger drink

Placebo: Super pure water

Placebo Comparator group

Description:

Super Pure water low in nitrate content

Treatment:

Dietary Supplement: Placebo: Super pure water