Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue

German Institute of Human Nutrition

Status: Completed

Conditions: Obesity; Insulin Sensitivity; Metabolic Syndrome

Treatments: Other: Glucose dependent insulinotropic polypeptide (GIP)

Study type: Interventional

Funder types: Other

Identifiers

NCT00774488

GIP-Genexpression Study

Details and patient eligibility

About

This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.

Enrollment: 17 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI > 28
• Healthy subjects
• Normal glucose tolerance

Exclusion criteria

• Diabetes,IFG, IGT
• Chronical-inflammatory diseases
• Hb < 12g/dl
• Elevation in liver enzymes or creatinin concentrations
• Great weight changes within last 12 months
• Any cancer diagnosis in last 10 years

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind