Acute Effects of High Impact Exercise on Bone Metabolism

Loughborough University

Status: Active, not recruiting

Conditions: Health Adults

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT07245225

16204

Details and patient eligibility

About

The goal of this study is to investigate the acute effects of drop-landing exercise on the bone metabolism biomarkers and extracellular vesicles in healthy young males, in order to gain a deeper understanding of the mechanotransduction mechanisms involved in bone metabolism.

The main question aims to answer:

• Does a single bout acute drop-landing exercise change serum sclerostin, other bone signaling markers, and circulating extracellular vesicles levels?

Participants complete both the drop-landing and control trials in a randomized order, with a minimum washout period of one week between trials. During each trial, blood samples are collected at three time points: pre-, immediately post, and 1-hour post drop-landing/control exercise.

Enrollment: 15 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-35 years old
• Healthy
• Male
• Body mass index (BMI) of 18.5-29.9
• Can understand and follow trial instructions

Exclusion criteria

• Have any uncontrolled cardiovascular or respiratory disease
• Have severe musculoskeletal or neurological disease likely to affect ability to perform an exercise
• Have medical conditions known to affect musculoskeletal health
• Have medications known to affect bone metabolism (e.g., corticosteroids, thyroxine, antiepileptic, and antiretroviral agents)
• Regular (more than once per week) participation in high-intensity resistance or impact-type exercise in the past 6 months
• Current smoker or vaper

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Arm Drop-landing + Control

Experimental group

Description:

According to the results of random allocation, participants first perform the drop-landing trial, followed by the control trial, with a minimum interval of one week between the two trials.

Treatment:

Behavioral: Exercise

Arm Control + Drop-landing

Experimental group

Description:

According to the results of random allocation, participants first perform the control trial, followed by the drop-landing trial, with a minimum interval of one week between the two trials.

Treatment:

Behavioral: Exercise